Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP<sup>5+</sup>, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats

Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP<sup>5+</sup>, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats

Endovascular mechanical thrombectomy, combined with a tissue plasminogen activator (t-PA), is efficacious as a standard care for qualifying ischemic stroke patients. However, > 50% of thrombectomy patients still have poor outcomes. Manganese porphyrins, commonly known as mimics of superoxide dism...

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Bibliographic Details
Main Authors: Xuan Li, Weina Duan, Li Du, Dongmei Chu, Peng Wang, Zhong Yang, Xingguang Qu, Zhenxing Yang, Ines Batinic-Haberle, Ivan Spasojevic, David S. Warner, James D. Crapo, Miriam M. Treggiari, Huaxin Sheng
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antioxidants
Subjects:
ischemic stroke
thrombectomy
BMX-001
manganese porphyrin
intracarotid
long-term, 28-day post-stroke outcome
Online Access:https://www.mdpi.com/2076-3921/12/10/1861

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