A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli
L-tryptophan and its derivatives are widely used in the chemical, pharmaceutical, food, and feed industries. Microbial fermentation is the most commonly used method to produce L-tryptophan, which calls for an effective cell factory. The mechanism of L-tryptophan biosynthesis in Escherichia coli, the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1261832/full |
| _version_ | 1797405532244410368 |
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| author | Xinru Ren Yue Wei Honglu Zhao Juanjuan Shao Fanli Zeng Fanli Zeng Zhen Wang Zhen Wang Li Li |
| author_facet | Xinru Ren Yue Wei Honglu Zhao Juanjuan Shao Fanli Zeng Fanli Zeng Zhen Wang Zhen Wang Li Li |
| author_sort | Xinru Ren |
| collection | DOAJ |
| description | L-tryptophan and its derivatives are widely used in the chemical, pharmaceutical, food, and feed industries. Microbial fermentation is the most commonly used method to produce L-tryptophan, which calls for an effective cell factory. The mechanism of L-tryptophan biosynthesis in Escherichia coli, the widely used producer of L-tryptophan, is well understood. Saccharomyces cerevisiae also plays a significant role in the industrial production of biochemicals. Because of its robustness and safety, S. cerevisiae is favored for producing pharmaceuticals and food-grade biochemicals. However, the biosynthesis of L-tryptophan in S. cerevisiae has been rarely summarized. The synthetic pathways and engineering strategies of L-tryptophan in E. coli and S. cerevisiae have been reviewed and compared in this review. Furthermore, the information presented in this review pertains to the existing understanding of how L-tryptophan affects S. cerevisiae’s stress fitness, which could aid in developing a novel plan to produce more resilient industrial yeast and E. coli cell factories. |
| first_indexed | 2024-03-09T03:11:23Z |
| format | Article |
| id | doaj.art-cd7d4fcb869b41f4852149ad0ba47079 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-09T03:11:23Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-cd7d4fcb869b41f4852149ad0ba470792023-12-04T04:42:12ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-12-011110.3389/fbioe.2023.12618321261832A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coliXinru Ren0Yue Wei1Honglu Zhao2Juanjuan Shao3Fanli Zeng4Fanli Zeng5Zhen Wang6Zhen Wang7Li Li8College of Science and Technology, Hebei Agricultural University, Cangzhou, ChinaCollege of Science and Technology, Hebei Agricultural University, Cangzhou, ChinaCollege of Science and Technology, Hebei Agricultural University, Cangzhou, ChinaCollege of Science and Technology, Hebei Agricultural University, Cangzhou, ChinaCollege of Life Sciences, Hebei Agricultural University, Baoding, ChinaHebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism, Baoding, ChinaCollege of Science and Technology, Hebei Agricultural University, Cangzhou, ChinaHebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism, Baoding, ChinaCollege of Science and Technology, Hebei Agricultural University, Cangzhou, ChinaL-tryptophan and its derivatives are widely used in the chemical, pharmaceutical, food, and feed industries. Microbial fermentation is the most commonly used method to produce L-tryptophan, which calls for an effective cell factory. The mechanism of L-tryptophan biosynthesis in Escherichia coli, the widely used producer of L-tryptophan, is well understood. Saccharomyces cerevisiae also plays a significant role in the industrial production of biochemicals. Because of its robustness and safety, S. cerevisiae is favored for producing pharmaceuticals and food-grade biochemicals. However, the biosynthesis of L-tryptophan in S. cerevisiae has been rarely summarized. The synthetic pathways and engineering strategies of L-tryptophan in E. coli and S. cerevisiae have been reviewed and compared in this review. Furthermore, the information presented in this review pertains to the existing understanding of how L-tryptophan affects S. cerevisiae’s stress fitness, which could aid in developing a novel plan to produce more resilient industrial yeast and E. coli cell factories.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1261832/fullL-tryptophanSaccharomyces cerevisiaeEscherichia colibiosynthesisstress fitness |
| spellingShingle | Xinru Ren Yue Wei Honglu Zhao Juanjuan Shao Fanli Zeng Fanli Zeng Zhen Wang Zhen Wang Li Li A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli Frontiers in Bioengineering and Biotechnology L-tryptophan Saccharomyces cerevisiae Escherichia coli biosynthesis stress fitness |
| title | A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli |
| title_full | A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli |
| title_fullStr | A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli |
| title_full_unstemmed | A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli |
| title_short | A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli |
| title_sort | comprehensive review and comparison of l tryptophan biosynthesis in saccharomyces cerevisiae and escherichia coli |
| topic | L-tryptophan Saccharomyces cerevisiae Escherichia coli biosynthesis stress fitness |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1261832/full |
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