Infectious Mononucleosis and Cholestatic Hepatitis: A Rare Association
Infectious mononucleosis is one of the major clinical manifestations of Epstein-Barr virus infection. In this syndrome, elevation of liver transaminase levels is common but cholestasis is rare, with few cases described in the literature. We present the case of a 14-year-old female adolescent, admitt...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
2017-12-01
|
| Series: | Acta Médica Portuguesa |
| Subjects: | |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8715 |
| _version_ | 1811342091485184000 |
|---|---|
| author | Catarina Salgado Ana Margarida Garcia Catarina Rúbio Florbela Cunha |
| author_facet | Catarina Salgado Ana Margarida Garcia Catarina Rúbio Florbela Cunha |
| author_sort | Catarina Salgado |
| collection | DOAJ |
| description | Infectious mononucleosis is one of the major clinical manifestations of Epstein-Barr virus infection. In this syndrome, elevation of liver transaminase levels is common but cholestasis is rare, with few cases described in the literature. We present the case of a 14-year-old female adolescent, admitted to the Emergency Room with fever, odynophagia and cervical adenomegaly. She was treated with amoxicillin and two days later he presented with jaundice. The analytical evaluation was compatible with cholestatic hepatitis and abdominal ultrasound revealed hepatosplenomegaly without dilatation of the bile ducts. The diagnosis of Epstein-Barr virus infection was confirmed by the presence of serological markers. This case aims to raise awareness of a rare manifestation of a common infectious agent and, consequently, to the inclusion of acute Epstein-Barr virus infection in the differential diagnosis of pediatric cholestatic hepatitis. |
| first_indexed | 2024-04-13T19:05:11Z |
| format | Article |
| id | doaj.art-cd7d545467eb4f96933e93839d75a985 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-13T19:05:11Z |
| publishDate | 2017-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-cd7d545467eb4f96933e93839d75a9852022-12-22T02:34:00ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582017-12-01301288688810.20344/amp.87154591Infectious Mononucleosis and Cholestatic Hepatitis: A Rare AssociationCatarina Salgado0Ana Margarida Garcia1Catarina Rúbio2Florbela Cunha3Departamento de Pediatria. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa.Departamento da Mulher, Criança e Adolescente. Centro Hospitalar Lisboa Central. Lisboa.Serviço de Pediatria. Hospital Vila Franca de Xira. Vila Franca de Xira.Serviço de Pediatria. Hospital Vila Franca de Xira. Vila Franca de Xira.Infectious mononucleosis is one of the major clinical manifestations of Epstein-Barr virus infection. In this syndrome, elevation of liver transaminase levels is common but cholestasis is rare, with few cases described in the literature. We present the case of a 14-year-old female adolescent, admitted to the Emergency Room with fever, odynophagia and cervical adenomegaly. She was treated with amoxicillin and two days later he presented with jaundice. The analytical evaluation was compatible with cholestatic hepatitis and abdominal ultrasound revealed hepatosplenomegaly without dilatation of the bile ducts. The diagnosis of Epstein-Barr virus infection was confirmed by the presence of serological markers. This case aims to raise awareness of a rare manifestation of a common infectious agent and, consequently, to the inclusion of acute Epstein-Barr virus infection in the differential diagnosis of pediatric cholestatic hepatitis.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8715AdolescenteColestaseHepatiteInfecções por Vírus Epstein-BarrMononucleose InfecciosaVírus Epstein-Barr |
| spellingShingle | Catarina Salgado Ana Margarida Garcia Catarina Rúbio Florbela Cunha Infectious Mononucleosis and Cholestatic Hepatitis: A Rare Association Acta Médica Portuguesa Adolescente Colestase Hepatite Infecções por Vírus Epstein-Barr Mononucleose Infecciosa Vírus Epstein-Barr |
| title | Infectious Mononucleosis and Cholestatic Hepatitis: A Rare Association |
| title_full | Infectious Mononucleosis and Cholestatic Hepatitis: A Rare Association |
| title_fullStr | Infectious Mononucleosis and Cholestatic Hepatitis: A Rare Association |
| title_full_unstemmed | Infectious Mononucleosis and Cholestatic Hepatitis: A Rare Association |
| title_short | Infectious Mononucleosis and Cholestatic Hepatitis: A Rare Association |
| title_sort | infectious mononucleosis and cholestatic hepatitis a rare association |
| topic | Adolescente Colestase Hepatite Infecções por Vírus Epstein-Barr Mononucleose Infecciosa Vírus Epstein-Barr |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8715 |
| work_keys_str_mv | AT catarinasalgado infectiousmononucleosisandcholestatichepatitisarareassociation AT anamargaridagarcia infectiousmononucleosisandcholestatichepatitisarareassociation AT catarinarubio infectiousmononucleosisandcholestatichepatitisarareassociation AT florbelacunha infectiousmononucleosisandcholestatichepatitisarareassociation |