Antiprotozoal Activity of Benzoylthiourea Derivatives against <i>Trypanosoma cruzi</i>: Insights into Mechanism of Action

Antiprotozoal Activity of Benzoylthiourea Derivatives against <i>Trypanosoma cruzi</i>: Insights into Mechanism of Action

For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for Chagas disease. However, these drugs present limited effectiveness during the chronic phase, possess unfavorable pharmacokinetic properties, and induce severe adverse effects, resulting in low treatment adherence....

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Main Authors: Patrícia Morais Lopes Pereira, Bruna Terci Fernandes, Vitória Ribeiro dos Santos, Weslei Roberto Correia Cabral, Maria Isabel Lovo-Martins, Lais Alonso, César Armando Contreras Lancheros, Jéssica Carreira de Paula, Priscila Goes Camargo, Helena Tiemi Suzukawa, Antônio Alonso, Fernando Macedo, Celso Vataru Nakamura, Eliandro Reis Tavares, Marcelle de Lima Ferreira Bispo, Lucy Megumi Yamauchi, Phileno Pinge-Filho, Sueli Fumie Yamada-Ogatta
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pathogens
Subjects:
autophagy-dependent pathway
cell death
Chagas disease
epimastigote forms
mechanism of action
ultrastructural changes
Online Access:https://www.mdpi.com/2076-0817/12/8/1012

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