Dopamine prevents lipid peroxidation-induced accumulation of toxic α-synuclein oligomers by preserving autophagy-lysosomal function

Dopamine prevents lipid peroxidation-induced accumulation of toxic α-synuclein oligomers by preserving autophagy-lysosomal function

The formation of Lewy bodies containing α-synuclein (α-syn), prominent loss of dopaminergic neurons and dopamine (DA) deficiency in substantia nigra and striatum are histopathological and biochemical hallmarks of Parkinson’s disease (PD). Multiple lines of evidence have indicated that a critical pat...

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Bibliographic Details
Main Authors: Peizhou eJiang, Ming eGan, Shu-Hui eYen
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Autophagy
Dopamine
Aggregation
Parkinson’s disease
α-Synuclein
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00081/full

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