A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle
Abstract A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate (OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate dehydrogenase. We purified from cow heart mitochondria an enzyme (OAT1) with OAA tautomerase (OAT) activity that conv...
Main Authors: | Anthony J. Zmuda, Xiaojun Kang, Katie B. Wissbroecker, Katrina Freund Saxhaug, Kyle C. Costa, Adrian D. Hegeman, Thomas D. Niehaus |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-45134-0 |
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