A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

Abstract A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate (OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate dehydrogenase. We purified from cow heart mitochondria an enzyme (OAT1) with OAA tautomerase (OAT) activity that conv...

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Bibliographic Details
Main Authors: Anthony J. Zmuda, Xiaojun Kang, Katie B. Wissbroecker, Katrina Freund Saxhaug, Kyle C. Costa, Adrian D. Hegeman, Thomas D. Niehaus
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45134-0

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