A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H2O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/5/1652/ |
| _version_ | 1818960324740513792 |
|---|---|
| author | Yanhong Wang Zhen Hu Xiangli Meng Jiehui Jing Yuanjun Song Chunhua Zhang Yudong Huang |
| author_facet | Yanhong Wang Zhen Hu Xiangli Meng Jiehui Jing Yuanjun Song Chunhua Zhang Yudong Huang |
| author_sort | Yanhong Wang |
| collection | DOAJ |
| description | A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H2O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H2/Pd/C/C2H5OH system was developed. The products were characterized by TG, IR, 1H-NMR, 13C-NMR, HPLC and elemental analysis. |
| first_indexed | 2024-12-20T11:55:44Z |
| format | Article |
| id | doaj.art-cd84b0947a504ccc854ea9ab9cafe5b9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T11:55:44Z |
| publishDate | 2009-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cd84b0947a504ccc854ea9ab9cafe5b92022-12-21T19:41:40ZengMDPI AGMolecules1420-30492009-04-011451652165910.3390/molecules14051652A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride SaltYanhong WangZhen HuXiangli MengJiehui JingYuanjun SongChunhua ZhangYudong HuangA simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP·3HCl·H2O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H2/Pd/C/C2H5OH system was developed. The products were characterized by TG, IR, 1H-NMR, 13C-NMR, HPLC and elemental analysis.http://www.mdpi.com/1420-3049/14/5/1652/2356-TetraaminopyridineNitrationHydrogenationSynthesis |
| spellingShingle | Yanhong Wang Zhen Hu Xiangli Meng Jiehui Jing Yuanjun Song Chunhua Zhang Yudong Huang A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt Molecules 2 3 5 6-Tetraaminopyridine Nitration Hydrogenation Synthesis |
| title | A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt |
| title_full | A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt |
| title_fullStr | A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt |
| title_full_unstemmed | A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt |
| title_short | A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt |
| title_sort | simple and efficient route for preparing 2 3 5 6 tetraaminopyridine hydrochloride salt |
| topic | 2 3 5 6-Tetraaminopyridine Nitration Hydrogenation Synthesis |
| url | http://www.mdpi.com/1420-3049/14/5/1652/ |
| work_keys_str_mv | AT yanhongwang asimpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT zhenhu asimpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT xianglimeng asimpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT jiehuijing asimpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT yuanjunsong asimpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT chunhuazhang asimpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT yudonghuang asimpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT yanhongwang simpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT zhenhu simpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT xianglimeng simpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT jiehuijing simpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT yuanjunsong simpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT chunhuazhang simpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt AT yudonghuang simpleandefficientrouteforpreparing2356tetraaminopyridinehydrochloridesalt |