High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

Summary: Zika virus (ZIKV) infection causes Guillain-Barré syndrome and severe birth defects. ZIKV envelope (E) protein is the major viral protein involved in cell receptor binding and entry and is therefore considered one of the major determinants in ZIKV pathogenesis. Here we report a gene-wide ma...

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Bibliographic Details
Main Authors: Danyang Gong, Tian-Hao Zhang, Dawei Zhao, Yushen Du, Travis J. Chapa, Yuan Shi, Laurie Wang, Deisy Contreras, Gang Zeng, Pei-Yong Shi, Ting-Ting Wu, Vaithilingaraja Arumugaswami, Ren Sun
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300099

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