NF-κB-Mediated Regulation of Osteoclastogenesis
Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding of the molecular mechanisms regulating osteoclast formation and functions have been ma...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2015-03-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-35.pdf |
| _version_ | 1818357839114010624 |
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| author | Brendan F. Boyce Yan Xiu Jinbo Li Lianping Xing Zhenqiang Yao |
| author_facet | Brendan F. Boyce Yan Xiu Jinbo Li Lianping Xing Zhenqiang Yao |
| author_sort | Brendan F. Boyce |
| collection | DOAJ |
| description | Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding of the molecular mechanisms regulating osteoclast formation and functions have been made in the past 20 years since the discovery that their formation requires nuclear factor-kappa B (NF-κB) signaling and that this is activated in response to the essential osteoclastogenic cytokine, receptor activator of NF-κB ligand (RANKL), which also controls osteoclast activation to resorb (degrade) bone. These studies have revealed that RANKL and some pro-inflammatory cytokines, including tumor necrosis factor, activate NF-κB and downstream signaling, including c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), and inhibition of repressors of NFATc1 signaling, to positively regulate osteoclast formation and functions. However, these cytokines also activate NF-κB signaling that can limit osteoclast formation through the NF-κB signaling proteins, TRAF3 and p100, and the suppressors of c-Fos/NFATc1 signaling, IRF8, and RBP-J. This paper reviews current understanding of how NF-κB signaling is involved in the positive and negative regulation of cytokine-mediated osteoclast formation and activation. |
| first_indexed | 2024-12-13T20:19:29Z |
| format | Article |
| id | doaj.art-cd85988a34694c718ef4d47927f0db3a |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T20:19:29Z |
| publishDate | 2015-03-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-cd85988a34694c718ef4d47927f0db3a2022-12-21T23:32:44ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782015-03-01301354410.3803/EnM.2015.30.1.3520829NF-κB-Mediated Regulation of OsteoclastogenesisBrendan F. BoyceYan XiuJinbo LiLianping XingZhenqiang YaoOsteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding of the molecular mechanisms regulating osteoclast formation and functions have been made in the past 20 years since the discovery that their formation requires nuclear factor-kappa B (NF-κB) signaling and that this is activated in response to the essential osteoclastogenic cytokine, receptor activator of NF-κB ligand (RANKL), which also controls osteoclast activation to resorb (degrade) bone. These studies have revealed that RANKL and some pro-inflammatory cytokines, including tumor necrosis factor, activate NF-κB and downstream signaling, including c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), and inhibition of repressors of NFATc1 signaling, to positively regulate osteoclast formation and functions. However, these cytokines also activate NF-κB signaling that can limit osteoclast formation through the NF-κB signaling proteins, TRAF3 and p100, and the suppressors of c-Fos/NFATc1 signaling, IRF8, and RBP-J. This paper reviews current understanding of how NF-κB signaling is involved in the positive and negative regulation of cytokine-mediated osteoclast formation and activation.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-35.pdfNF-kappa BOsteoclastsRANK ligandTumor necrosis factorTNF receptor-associated factor 3NF-kappa B kinase |
| spellingShingle | Brendan F. Boyce Yan Xiu Jinbo Li Lianping Xing Zhenqiang Yao NF-κB-Mediated Regulation of Osteoclastogenesis Endocrinology and Metabolism NF-kappa B Osteoclasts RANK ligand Tumor necrosis factor TNF receptor-associated factor 3 NF-kappa B kinase |
| title | NF-κB-Mediated Regulation of Osteoclastogenesis |
| title_full | NF-κB-Mediated Regulation of Osteoclastogenesis |
| title_fullStr | NF-κB-Mediated Regulation of Osteoclastogenesis |
| title_full_unstemmed | NF-κB-Mediated Regulation of Osteoclastogenesis |
| title_short | NF-κB-Mediated Regulation of Osteoclastogenesis |
| title_sort | nf κb mediated regulation of osteoclastogenesis |
| topic | NF-kappa B Osteoclasts RANK ligand Tumor necrosis factor TNF receptor-associated factor 3 NF-kappa B kinase |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-35.pdf |
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