Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study
Abdominal ultrasound exams play a major role in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). The development of portable hand-held ultrasound devices (HHUS) has been shown to facilitate the diagnosis of many diseases, but little data on the value of HHUS in the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/2/520 |
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| author | Andrea Duminuco Alessandra Cupri Rosario Massimino Salvatore Leotta Giulio Antonio Milone Bruno Garibaldi Giulia Giuffrida Orazio Garretto Giuseppe Milone |
| author_facet | Andrea Duminuco Alessandra Cupri Rosario Massimino Salvatore Leotta Giulio Antonio Milone Bruno Garibaldi Giulia Giuffrida Orazio Garretto Giuseppe Milone |
| author_sort | Andrea Duminuco |
| collection | DOAJ |
| description | Abdominal ultrasound exams play a major role in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). The development of portable hand-held ultrasound devices (HHUS) has been shown to facilitate the diagnosis of many diseases, but little data on the value of HHUS in the diagnosis of SOS/VOD are available. We performed a study aimed at validating portable ultrasound (US) devices in the setting of hematopoietic stem cell transplant (HCT). Sixteen evaluable patients undergoing allogeneic HCT were studied using conventional US and HHUS during the first 3 weeks after transplant. The results obtained demonstrate that there is a close correlation between conventional and handheld ultrasound examination in the measurement of the right hepatic lobe (r = 0.912, <i>p</i> < 0.0001), the left hepatic lobe (r = 0.843, <i>p</i> < 0.0001), the portal vein (PV) (r = 0.724, <i>p</i> < 0.0001), and the spleen (r = 0.983, <i>p</i> < 0.0001) based on Pearson’s correlation. The same data, analyzed through Lin’s concordance correlation coefficient, evidenced a substantial level of agreement in the comparison of the spleen and right hepatic lobe, while a lower grade of agreement in the measurement of the portal vein and left hepatic lobe. Moreover, there was good agreement between results obtained by the two types of ultrasound devices in assessing ascites (<i>p</i> < 0.0001), gallbladder thickening (<i>p</i> < 0.0001), and the direction of PV flow (<i>p</i> < 0.0001). HHUS device allows the study of HokUs-10 parameters with an excellent agreement with conventional US, and may contribute to SOS/VOD diagnosis. |
| first_indexed | 2024-03-09T12:12:10Z |
| format | Article |
| id | doaj.art-cd8649538be94147a60af54c14e21baf |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:12:10Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cd8649538be94147a60af54c14e21baf2023-11-30T22:51:04ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112252010.3390/jcm12020520Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation StudyAndrea Duminuco0Alessandra Cupri1Rosario Massimino2Salvatore Leotta3Giulio Antonio Milone4Bruno Garibaldi5Giulia Giuffrida6Orazio Garretto7Giuseppe Milone8Unità di Trapianto Emopoietico, Divisione di Ematologia, Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyUnità di Trapianto Emopoietico, Divisione di Ematologia, Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyRadiologia CAST Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyUnità di Trapianto Emopoietico, Divisione di Ematologia, Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyIstituto Oncologico del Mediterraneo, Unità di Trapianto Emopoietico, Divisione di Ematologia, 95029 Viagrande, ItalyUnità di Trapianto Emopoietico, Divisione di Ematologia, Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyUnità di Trapianto Emopoietico, Divisione di Ematologia, Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyRadiologia CAST Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyUnità di Trapianto Emopoietico, Divisione di Ematologia, Azienda Ospedaliera Policlinico “G.Rodolico-San Marco”, 95123 Catania, ItalyAbdominal ultrasound exams play a major role in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). The development of portable hand-held ultrasound devices (HHUS) has been shown to facilitate the diagnosis of many diseases, but little data on the value of HHUS in the diagnosis of SOS/VOD are available. We performed a study aimed at validating portable ultrasound (US) devices in the setting of hematopoietic stem cell transplant (HCT). Sixteen evaluable patients undergoing allogeneic HCT were studied using conventional US and HHUS during the first 3 weeks after transplant. The results obtained demonstrate that there is a close correlation between conventional and handheld ultrasound examination in the measurement of the right hepatic lobe (r = 0.912, <i>p</i> < 0.0001), the left hepatic lobe (r = 0.843, <i>p</i> < 0.0001), the portal vein (PV) (r = 0.724, <i>p</i> < 0.0001), and the spleen (r = 0.983, <i>p</i> < 0.0001) based on Pearson’s correlation. The same data, analyzed through Lin’s concordance correlation coefficient, evidenced a substantial level of agreement in the comparison of the spleen and right hepatic lobe, while a lower grade of agreement in the measurement of the portal vein and left hepatic lobe. Moreover, there was good agreement between results obtained by the two types of ultrasound devices in assessing ascites (<i>p</i> < 0.0001), gallbladder thickening (<i>p</i> < 0.0001), and the direction of PV flow (<i>p</i> < 0.0001). HHUS device allows the study of HokUs-10 parameters with an excellent agreement with conventional US, and may contribute to SOS/VOD diagnosis.https://www.mdpi.com/2077-0383/12/2/520hematopoietic stem cell transplantationhandheld ultrasound deviceliver veno-occlusive disease |
| spellingShingle | Andrea Duminuco Alessandra Cupri Rosario Massimino Salvatore Leotta Giulio Antonio Milone Bruno Garibaldi Giulia Giuffrida Orazio Garretto Giuseppe Milone Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study Journal of Clinical Medicine hematopoietic stem cell transplantation handheld ultrasound device liver veno-occlusive disease |
| title | Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study |
| title_full | Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study |
| title_fullStr | Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study |
| title_full_unstemmed | Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study |
| title_short | Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study |
| title_sort | handheld ultrasound or conventional ultrasound devices in patients undergoing hct a validation study |
| topic | hematopoietic stem cell transplantation handheld ultrasound device liver veno-occlusive disease |
| url | https://www.mdpi.com/2077-0383/12/2/520 |
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