Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE

Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE

Summary: Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression, and recurrence in glioblastoma (GBM). Hypoxia induces release of high-mobility group box 1 (HMGB1) from tumor cells, promoting the development of tumor. Here, we report that HMGB1 is overexpressed in...

Full description

Bibliographic Details
Main Authors: Cuifang Ye, Huan Li, Yachao Li, Yang Zhang, Guohao Liu, Hailong Mi, Honglian Li, Qungen Xiao, Li Niu, Xingjiang Yu
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Biological sciences
Cancer
Cell biology
Microenvironment
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222011440

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222011440

Similar Items