A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel
Protective agent for hepatotoxicity is still a great challenge in the management of liver diseases. Aloe vera is a beneficial plant that has been studied for food supplements, cosmetic and herbal medicine. Aloe vera contains many compounds which have a role in body health including polysaccharides,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Society for Cancer Chemoprevention
2022-03-01
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| Series: | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| Online Access: | https://ijcc.chemoprev.org/index.php/ijcc/article/view/392 |
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| author | Sri Handayani Dina Aprilia Khoirun Nisa Vita Taufika Rosyida Martha Purnami Wulanjati Anjar Windarsih Cici Darsih Andri Frediansyah Sari Haryanti |
| author_facet | Sri Handayani Dina Aprilia Khoirun Nisa Vita Taufika Rosyida Martha Purnami Wulanjati Anjar Windarsih Cici Darsih Andri Frediansyah Sari Haryanti |
| author_sort | Sri Handayani |
| collection | DOAJ |
| description | Protective agent for hepatotoxicity is still a great challenge in the management of liver diseases. Aloe vera is a beneficial plant that has been studied for food supplements, cosmetic and herbal medicine. Aloe vera contains many compounds which have a role in body health including polysaccharides, phenolic, flavonoid, terpenoid, amino acid, and several minerals. There have been compelling evidences that natural phytochemicals and their derivatives have hepatoprotective activities. Information of the aloe vera and its mechanism of action for possible hepatoprotective activities, including in silico, in vitro, and in vivo studies were obtained from Pubmed, Science Direct, Scopus, and Google scholar search engines. This current review was focusing on the possible contribution of compounds inside aloe vera gel and the suggestion of its mechanism on protective effect, especially for liver. The complexity of monosaccharides composition, backbone structures, acetyl group, and molecular weight of aloe polysaccharides have possible correlations with its hepatoprotective effect. Most of the hepatoprotective mechanisms of aloe compounds are related to their protective effect against inflammation and oxidative stress. Several compounds may have combination effects or several targets lead to synergistic effects.
Keywords: Aloe vera, food supplement, hepatoprotective, liver disease, mechanism of action. |
| first_indexed | 2024-12-12T13:55:55Z |
| format | Article |
| id | doaj.art-cd8ce2859ca5482a8116cfb81ef0561f |
| institution | Directory Open Access Journal |
| issn | 2088-0197 2355-8989 |
| language | English |
| last_indexed | 2024-12-12T13:55:55Z |
| publishDate | 2022-03-01 |
| publisher | Indonesian Society for Cancer Chemoprevention |
| record_format | Article |
| series | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| spelling | doaj.art-cd8ce2859ca5482a8116cfb81ef0561f2022-12-22T00:22:28ZengIndonesian Society for Cancer ChemopreventionISCC (Indonesian Journal of Cancer Chemoprevention)2088-01972355-89892022-03-0112317017910.14499/indonesianjcanchemoprev12iss3pp170-179235A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera GelSri Handayani0Dina Aprilia1Khoirun Nisa2Vita Taufika Rosyida3Martha Purnami Wulanjati4Anjar Windarsih5Cici Darsih6Andri Frediansyah7Sari Haryanti8Research Division for Natural product Technology, Badan Riset dan Inovasi Nasional (BRIN), Yogyakarta, Indonesia, 55861Undergraduate Student, Faculty of Mathematic and Natural Sciences, Universitas Lambung Mangkurat, Banjarbaru, Kalimantan Selatan, Indonesia, 70123Research Division for Natural product Technology, Badan Riset dan Inovasi Nasional (BRIN), Yogyakarta, Indonesia, 55861Research Division for Natural product Technology, Badan Riset dan Inovasi Nasional (BRIN), Yogyakarta, Indonesia, 55861Research Division for Natural product Technology, Badan Riset dan Inovasi Nasional (BRIN), Yogyakarta, Indonesia, 55861Research Division for Natural product Technology, Badan Riset dan Inovasi Nasional (BRIN), Yogyakarta, Indonesia, 55861Research Division for Natural product Technology, Badan Riset dan Inovasi Nasional (BRIN), Yogyakarta, Indonesia, 55861Research Division for Natural product Technology, Badan Riset dan Inovasi Nasional (BRIN), Yogyakarta, Indonesia, 55861Medicinal Plant and Traditional Medicine Research and Development Centre-NIHRD, Ministry of Health, Karanganyar, Jawa Tengah, Indonesia, 57792Protective agent for hepatotoxicity is still a great challenge in the management of liver diseases. Aloe vera is a beneficial plant that has been studied for food supplements, cosmetic and herbal medicine. Aloe vera contains many compounds which have a role in body health including polysaccharides, phenolic, flavonoid, terpenoid, amino acid, and several minerals. There have been compelling evidences that natural phytochemicals and their derivatives have hepatoprotective activities. Information of the aloe vera and its mechanism of action for possible hepatoprotective activities, including in silico, in vitro, and in vivo studies were obtained from Pubmed, Science Direct, Scopus, and Google scholar search engines. This current review was focusing on the possible contribution of compounds inside aloe vera gel and the suggestion of its mechanism on protective effect, especially for liver. The complexity of monosaccharides composition, backbone structures, acetyl group, and molecular weight of aloe polysaccharides have possible correlations with its hepatoprotective effect. Most of the hepatoprotective mechanisms of aloe compounds are related to their protective effect against inflammation and oxidative stress. Several compounds may have combination effects or several targets lead to synergistic effects. Keywords: Aloe vera, food supplement, hepatoprotective, liver disease, mechanism of action.https://ijcc.chemoprev.org/index.php/ijcc/article/view/392 |
| spellingShingle | Sri Handayani Dina Aprilia Khoirun Nisa Vita Taufika Rosyida Martha Purnami Wulanjati Anjar Windarsih Cici Darsih Andri Frediansyah Sari Haryanti A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel ISCC (Indonesian Journal of Cancer Chemoprevention) |
| title | A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel |
| title_full | A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel |
| title_fullStr | A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel |
| title_full_unstemmed | A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel |
| title_short | A Mini-Review: Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel |
| title_sort | mini review possible mechanisms of hepatoprotective effect of aloe vera gel |
| url | https://ijcc.chemoprev.org/index.php/ijcc/article/view/392 |
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