High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study
Abstract Aims/Introduction The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 diabetes mellitus and type 2 diabetes mellitus. Materials...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
|
| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13436 |
| _version_ | 1818863618071986176 |
|---|---|
| author | Hiroyasu Mori Akio Kuroda Sumiko Yoshida Tetsuyuki Yasuda Yutaka Umayahara Sayoko Shimizu Kayoko Ryomoto Kazutomi Yoshiuchi Tsunehiko Yamamoto Taka‐aki Matsuoka Iichiro Shimomura Munehide Matsuhisa |
| author_facet | Hiroyasu Mori Akio Kuroda Sumiko Yoshida Tetsuyuki Yasuda Yutaka Umayahara Sayoko Shimizu Kayoko Ryomoto Kazutomi Yoshiuchi Tsunehiko Yamamoto Taka‐aki Matsuoka Iichiro Shimomura Munehide Matsuhisa |
| author_sort | Hiroyasu Mori |
| collection | DOAJ |
| description | Abstract Aims/Introduction The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 diabetes mellitus and type 2 diabetes mellitus. Materials and Methods This cross‐sectional study enrolled 1,328 participants with type 1 diabetes (n = 177), type 2 diabetes (n = 645) and without diabetes (n = 506). Sarcopenia was defined as a low grip strength and slow gait speed with low skeletal muscle mass index, whereas dynapenia was defined as low strengths of grip and knee extension with a normal skeletal muscle mass index. Participants without sarcopenia and dynapenia were defined as robust. Results Among participants aged ≥65 years, sarcopenia and dynapenia were observed in 12.2% and 0.5% of individuals without diabetes, 42.9% and 11.4% of type 1 diabetes patients, and 20.9% and 13.9% of type 2 diabetes patients. In both type 1 diabetes and type 2 diabetes patients, sarcopenic patients were significantly older and thinner, and showed a significantly higher rate of diabetic neuropathy than robust patients. In patients with type 1 diabetes and type 2 diabetes, dynapenic patients were older, and showed a higher rate of diabetic neuropathy and lower estimated glomerular filtration rate than robust patients. Patients complicated with sarcopenia and dynapenia showed a significantly lower physical quality of life and higher rate of incidental falls than robust patients. Conclusions Sarcopenia and dynapenia were more frequent in patients with type 1 diabetes and type 2 diabetes than in individuals without diabetes, which might contribute to their impaired quality of life and incidental falls. |
| first_indexed | 2024-12-19T10:18:37Z |
| format | Article |
| id | doaj.art-cd8e1f72f0c541388250455a18d77ea9 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-19T10:18:37Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-cd8e1f72f0c541388250455a18d77ea92022-12-21T20:26:08ZengWileyJournal of Diabetes Investigation2040-11162040-11242021-06-011261050105910.1111/jdi.13436High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia studyHiroyasu Mori0Akio Kuroda1Sumiko Yoshida2Tetsuyuki Yasuda3Yutaka Umayahara4Sayoko Shimizu5Kayoko Ryomoto6Kazutomi Yoshiuchi7Tsunehiko Yamamoto8Taka‐aki Matsuoka9Iichiro Shimomura10Munehide Matsuhisa11Diabetes Therapeutics and Research Center Institute of Advanced Medical Sciences Tokushima University Tokushima JapanDiabetes Therapeutics and Research Center Institute of Advanced Medical Sciences Tokushima University Tokushima JapanDepartment of Hematology, Endocrinology and Metabolism Tokushima University Graduate School of Biomedical Sciences Tokushima JapanDepartment of Endocrinology and Metabolism Osaka Police Hospital Osaka JapanOsaka General Medical Center Osaka JapanOsaka General Medical Center Osaka JapanOsaka Rosai Hospital Osaka JapanOsaka Kaisei Hospital Osaka JapanKansai Rosai Hospital Hyogo JapanDepartment of Metabolic Medicine Graduate School of Medicine Osaka University Suita Osaka JapanDepartment of Metabolic Medicine Graduate School of Medicine Osaka University Suita Osaka JapanDiabetes Therapeutics and Research Center Institute of Advanced Medical Sciences Tokushima University Tokushima JapanAbstract Aims/Introduction The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 diabetes mellitus and type 2 diabetes mellitus. Materials and Methods This cross‐sectional study enrolled 1,328 participants with type 1 diabetes (n = 177), type 2 diabetes (n = 645) and without diabetes (n = 506). Sarcopenia was defined as a low grip strength and slow gait speed with low skeletal muscle mass index, whereas dynapenia was defined as low strengths of grip and knee extension with a normal skeletal muscle mass index. Participants without sarcopenia and dynapenia were defined as robust. Results Among participants aged ≥65 years, sarcopenia and dynapenia were observed in 12.2% and 0.5% of individuals without diabetes, 42.9% and 11.4% of type 1 diabetes patients, and 20.9% and 13.9% of type 2 diabetes patients. In both type 1 diabetes and type 2 diabetes patients, sarcopenic patients were significantly older and thinner, and showed a significantly higher rate of diabetic neuropathy than robust patients. In patients with type 1 diabetes and type 2 diabetes, dynapenic patients were older, and showed a higher rate of diabetic neuropathy and lower estimated glomerular filtration rate than robust patients. Patients complicated with sarcopenia and dynapenia showed a significantly lower physical quality of life and higher rate of incidental falls than robust patients. Conclusions Sarcopenia and dynapenia were more frequent in patients with type 1 diabetes and type 2 diabetes than in individuals without diabetes, which might contribute to their impaired quality of life and incidental falls.https://doi.org/10.1111/jdi.13436DynapeniaSarcopeniaType 1 and type 2 diabetes |
| spellingShingle | Hiroyasu Mori Akio Kuroda Sumiko Yoshida Tetsuyuki Yasuda Yutaka Umayahara Sayoko Shimizu Kayoko Ryomoto Kazutomi Yoshiuchi Tsunehiko Yamamoto Taka‐aki Matsuoka Iichiro Shimomura Munehide Matsuhisa High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study Journal of Diabetes Investigation Dynapenia Sarcopenia Type 1 and type 2 diabetes |
| title | High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study |
| title_full | High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study |
| title_fullStr | High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study |
| title_full_unstemmed | High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study |
| title_short | High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study |
| title_sort | high prevalence and clinical impact of dynapenia and sarcopenia in japanese patients with type 1 and type 2 diabetes findings from the impact of diabetes mellitus on dynapenia study |
| topic | Dynapenia Sarcopenia Type 1 and type 2 diabetes |
| url | https://doi.org/10.1111/jdi.13436 |
| work_keys_str_mv | AT hiroyasumori highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT akiokuroda highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT sumikoyoshida highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT tetsuyukiyasuda highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT yutakaumayahara highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT sayokoshimizu highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT kayokoryomoto highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT kazutomiyoshiuchi highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT tsunehikoyamamoto highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT takaakimatsuoka highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT iichiroshimomura highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy AT munehidematsuhisa highprevalenceandclinicalimpactofdynapeniaandsarcopeniainjapanesepatientswithtype1andtype2diabetesfindingsfromtheimpactofdiabetesmellitusondynapeniastudy |