COVID-19-Associated Encephalopathy—Case Series and Clinical Considerations
Neurological manifestations of the SARS-CoV-2 infection are present in up to 80% of the affected patients. While the majority of them is benign, in certain patients, viral replication in the central nervous system results in a severe disruption in cognitive function as well as basic life functions....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/4/981 |
| _version_ | 1797479140822089728 |
|---|---|
| author | Jakub Udzik Paweł Jakubowski Małgorzata Niekrasz Adrian Barczyszyn Miłosz Parczewski |
| author_facet | Jakub Udzik Paweł Jakubowski Małgorzata Niekrasz Adrian Barczyszyn Miłosz Parczewski |
| author_sort | Jakub Udzik |
| collection | DOAJ |
| description | Neurological manifestations of the SARS-CoV-2 infection are present in up to 80% of the affected patients. While the majority of them is benign, in certain patients, viral replication in the central nervous system results in a severe disruption in cognitive function as well as basic life functions. In this case series, the authors present a detailed description of the three SARS-CoV-2 infection cases, which were all complicated by severe encephalopathy. Consecutive neurological status changes were described for each patient with detailed imaging and clinical sequelae. In the discussion, the authors highlight similarities in the course of the disease in presented patients, as well as common features in test results. An effective causal treatment could not be introduced in any of the patients, nor could the progression of the central nervous system (CNS) damage be stopped. The authors hope that the experiences they gathered will help to accelerate the diagnostic and therapeutic process in other patients with COVID-19-associated encephalopathy and result in introducing an effective treatment. |
| first_indexed | 2024-03-09T21:41:39Z |
| format | Article |
| id | doaj.art-cd8f1dcfb3d5473e8cbe1be9b6737c64 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:41:39Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cd8f1dcfb3d5473e8cbe1be9b6737c642023-11-23T20:29:51ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-0111498110.3390/jcm11040981COVID-19-Associated Encephalopathy—Case Series and Clinical ConsiderationsJakub Udzik0Paweł Jakubowski1Małgorzata Niekrasz2Adrian Barczyszyn3Miłosz Parczewski4Department of Physiology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Neurosurgery and Neurotraumatology, Samodzielny Publiczny Wojewódzki Szpital Zespolony, Arkońska 4, 71-455 Szczecin, PolandDepartment of Neurology and Cerebral Stroke, Samodzielny Publiczny Wojewódzki Szpital Zespolony, Akrońska 4, 71-455 Szczecin, PolandDepartment of Radiology and Diagnostic Imaging, Samodzielny Publiczny Wojewódzki Szpital Zespolony, Arkońska 4, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Tropical Diseases and Immune Deficiency, Pomeranian Medical University in Szczecin, 71-455 Szczecin, PolandNeurological manifestations of the SARS-CoV-2 infection are present in up to 80% of the affected patients. While the majority of them is benign, in certain patients, viral replication in the central nervous system results in a severe disruption in cognitive function as well as basic life functions. In this case series, the authors present a detailed description of the three SARS-CoV-2 infection cases, which were all complicated by severe encephalopathy. Consecutive neurological status changes were described for each patient with detailed imaging and clinical sequelae. In the discussion, the authors highlight similarities in the course of the disease in presented patients, as well as common features in test results. An effective causal treatment could not be introduced in any of the patients, nor could the progression of the central nervous system (CNS) damage be stopped. The authors hope that the experiences they gathered will help to accelerate the diagnostic and therapeutic process in other patients with COVID-19-associated encephalopathy and result in introducing an effective treatment.https://www.mdpi.com/2077-0383/11/4/981COVID-19covid-associated encephalopathyCOVID-19 neurological complicationsneuroinfection |
| spellingShingle | Jakub Udzik Paweł Jakubowski Małgorzata Niekrasz Adrian Barczyszyn Miłosz Parczewski COVID-19-Associated Encephalopathy—Case Series and Clinical Considerations Journal of Clinical Medicine COVID-19 covid-associated encephalopathy COVID-19 neurological complications neuroinfection |
| title | COVID-19-Associated Encephalopathy—Case Series and Clinical Considerations |
| title_full | COVID-19-Associated Encephalopathy—Case Series and Clinical Considerations |
| title_fullStr | COVID-19-Associated Encephalopathy—Case Series and Clinical Considerations |
| title_full_unstemmed | COVID-19-Associated Encephalopathy—Case Series and Clinical Considerations |
| title_short | COVID-19-Associated Encephalopathy—Case Series and Clinical Considerations |
| title_sort | covid 19 associated encephalopathy case series and clinical considerations |
| topic | COVID-19 covid-associated encephalopathy COVID-19 neurological complications neuroinfection |
| url | https://www.mdpi.com/2077-0383/11/4/981 |
| work_keys_str_mv | AT jakubudzik covid19associatedencephalopathycaseseriesandclinicalconsiderations AT pawełjakubowski covid19associatedencephalopathycaseseriesandclinicalconsiderations AT małgorzataniekrasz covid19associatedencephalopathycaseseriesandclinicalconsiderations AT adrianbarczyszyn covid19associatedencephalopathycaseseriesandclinicalconsiderations AT miłoszparczewski covid19associatedencephalopathycaseseriesandclinicalconsiderations |