Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator
Magnetoencephalography (MEG) provides useful and non-redundant information in the evaluation of patients with epilepsy, and in particular during the pre-surgical evaluation of pharmaco-resistant epilepsy. Vagus nerve stimulation (VNS) is a common treatment for pharmaco-resistant epilepsy. However i...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-11-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00244/full |
| _version_ | 1818617175537090560 |
|---|---|
| author | Jennifer Rebecca Stapleton-Kotloski Robert Joseph Kotloski Robert Joseph Kotloski Jane A Boggs Gautam ePopli Cormac A O'Donovan Daniel E Couture Cassandra eCornell Dwayne eGodwin Dwayne eGodwin |
| author_facet | Jennifer Rebecca Stapleton-Kotloski Robert Joseph Kotloski Robert Joseph Kotloski Jane A Boggs Gautam ePopli Cormac A O'Donovan Daniel E Couture Cassandra eCornell Dwayne eGodwin Dwayne eGodwin |
| author_sort | Jennifer Rebecca Stapleton-Kotloski |
| collection | DOAJ |
| description | Magnetoencephalography (MEG) provides useful and non-redundant information in the evaluation of patients with epilepsy, and in particular during the pre-surgical evaluation of pharmaco-resistant epilepsy. Vagus nerve stimulation (VNS) is a common treatment for pharmaco-resistant epilepsy. However interpretation of MEG recordings from patients with a VNS is challenging due to the severe magnetic artifacts produced by the VNS. We used synthetic aperture magnetometry (g2) (SAM(g2), an adaptive beamformer that maps the excessive kurtosis, to map interictal spikes to the coregistered MRI image, despite the presence of contaminating VNS artifact. We present a series of eight patients with a VNS who underwent MEG recording. Localization of interictal epileptiform activity by SAM(g2) is compared to invasive electrophysiologic monitoring and other localizing approaches. While the raw MEG recordings were uninterpretable, analysis of the recordings with SAM(g2) identified foci of peak kurtosis and source signal activity that was unaffected by the VNS artifact. SAM(g2) analysis of MEG recordings in patients with a VNS produces interpretable results and expands the use of MEG for the pre-surgical evaluation of epilepsy. |
| first_indexed | 2024-12-16T17:01:31Z |
| format | Article |
| id | doaj.art-cd8fb4fafcc54bcdbc5f07068b0bc10a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T17:01:31Z |
| publishDate | 2014-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-cd8fb4fafcc54bcdbc5f07068b0bc10a2022-12-21T22:23:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952014-11-01510.3389/fneur.2014.00244116177Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve StimulatorJennifer Rebecca Stapleton-Kotloski0Robert Joseph Kotloski1Robert Joseph Kotloski2Jane A Boggs3Gautam ePopli4Cormac A O'Donovan5Daniel E Couture6Cassandra eCornell7Dwayne eGodwin8Dwayne eGodwin9Wake Forest University School of MedicineWilliam S Middleton Memorial Veterans HospitalUniversity of Wisconsin School of Medicine and Public HealthWake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicineWake Forest University School of MedicineMagnetoencephalography (MEG) provides useful and non-redundant information in the evaluation of patients with epilepsy, and in particular during the pre-surgical evaluation of pharmaco-resistant epilepsy. Vagus nerve stimulation (VNS) is a common treatment for pharmaco-resistant epilepsy. However interpretation of MEG recordings from patients with a VNS is challenging due to the severe magnetic artifacts produced by the VNS. We used synthetic aperture magnetometry (g2) (SAM(g2), an adaptive beamformer that maps the excessive kurtosis, to map interictal spikes to the coregistered MRI image, despite the presence of contaminating VNS artifact. We present a series of eight patients with a VNS who underwent MEG recording. Localization of interictal epileptiform activity by SAM(g2) is compared to invasive electrophysiologic monitoring and other localizing approaches. While the raw MEG recordings were uninterpretable, analysis of the recordings with SAM(g2) identified foci of peak kurtosis and source signal activity that was unaffected by the VNS artifact. SAM(g2) analysis of MEG recordings in patients with a VNS produces interpretable results and expands the use of MEG for the pre-surgical evaluation of epilepsy.http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00244/fullEpilepsyMagnetoencephalographysynthetic aperture magnetometryvagus nerve stimulatorepilepsy surgical evaluation |
| spellingShingle | Jennifer Rebecca Stapleton-Kotloski Robert Joseph Kotloski Robert Joseph Kotloski Jane A Boggs Gautam ePopli Cormac A O'Donovan Daniel E Couture Cassandra eCornell Dwayne eGodwin Dwayne eGodwin Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator Frontiers in Neurology Epilepsy Magnetoencephalography synthetic aperture magnetometry vagus nerve stimulator epilepsy surgical evaluation |
| title | Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator |
| title_full | Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator |
| title_fullStr | Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator |
| title_full_unstemmed | Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator |
| title_short | Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator |
| title_sort | localization of interictal epileptiform activity using magnetoencephalography with synthetic aperture magnetometry in patients with a vagus nerve stimulator |
| topic | Epilepsy Magnetoencephalography synthetic aperture magnetometry vagus nerve stimulator epilepsy surgical evaluation |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00244/full |
| work_keys_str_mv | AT jenniferrebeccastapletonkotloski localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT robertjosephkotloski localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT robertjosephkotloski localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT janeaboggs localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT gautamepopli localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT cormacaodonovan localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT danielecouture localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT cassandraecornell localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT dwayneegodwin localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator AT dwayneegodwin localizationofinterictalepileptiformactivityusingmagnetoencephalographywithsyntheticaperturemagnetometryinpatientswithavagusnervestimulator |