A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy
In this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide signal enha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/8/2554 |
| _version_ | 1797409909135900672 |
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| author | Setumo Lebogang Thobakgale Saturnin Ombinda-Lemboumba Patience Mthunzi-Kufa |
| author_facet | Setumo Lebogang Thobakgale Saturnin Ombinda-Lemboumba Patience Mthunzi-Kufa |
| author_sort | Setumo Lebogang Thobakgale |
| collection | DOAJ |
| description | In this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide signal enhancement of the drugs using SERS. Aspirin (10% <i>w</i>/<i>v</i>) and tenofovir (20% <i>v</i>/<i>v</i>) were analysed in the presence of the nanomaterials to determine trends in molecular response to changes in gold/dextran concentrations. Qualitative analysis of the functional groups showed specific trends where the peak area increased with polarizability, electron density and decreased atomic radii. Steric hinderance effects also affected the trends in peak area due to the amount of gold/dextran nanoparticles in solution. Statistical analysis provided accurate and precise linear relationships (R<sup>2</sup> = 0.99) for the ester and adenine functional groups of aspirin and tenofovir, respectively. From the above findings, the combined use of gold nano-scaffolds and gold/dextran nanomaterials amplified the Raman signal from the drugs to allow for systematic evaluation of their molecular properties. Although more experiments to correlate the findings are still needed, this SERS approach shows great potential as a screening method in the quality control of medications. |
| first_indexed | 2024-03-09T04:21:20Z |
| format | Article |
| id | doaj.art-cd9057ab235743b29b69535628f55247 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:21:20Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cd9057ab235743b29b69535628f552472023-12-03T13:46:53ZengMDPI AGMolecules1420-30492022-04-01278255410.3390/molecules27082554A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman SpectroscopySetumo Lebogang Thobakgale0Saturnin Ombinda-Lemboumba1Patience Mthunzi-Kufa2National Laser Centre, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001, South AfricaNational Laser Centre, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001, South AfricaNational Laser Centre, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001, South AfricaIn this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide signal enhancement of the drugs using SERS. Aspirin (10% <i>w</i>/<i>v</i>) and tenofovir (20% <i>v</i>/<i>v</i>) were analysed in the presence of the nanomaterials to determine trends in molecular response to changes in gold/dextran concentrations. Qualitative analysis of the functional groups showed specific trends where the peak area increased with polarizability, electron density and decreased atomic radii. Steric hinderance effects also affected the trends in peak area due to the amount of gold/dextran nanoparticles in solution. Statistical analysis provided accurate and precise linear relationships (R<sup>2</sup> = 0.99) for the ester and adenine functional groups of aspirin and tenofovir, respectively. From the above findings, the combined use of gold nano-scaffolds and gold/dextran nanomaterials amplified the Raman signal from the drugs to allow for systematic evaluation of their molecular properties. Although more experiments to correlate the findings are still needed, this SERS approach shows great potential as a screening method in the quality control of medications.https://www.mdpi.com/1420-3049/27/8/2554aspirintenofovirgold nanoparticlesdextranchemical sensorsSERS |
| spellingShingle | Setumo Lebogang Thobakgale Saturnin Ombinda-Lemboumba Patience Mthunzi-Kufa A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy Molecules aspirin tenofovir gold nanoparticles dextran chemical sensors SERS |
| title | A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy |
| title_full | A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy |
| title_fullStr | A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy |
| title_full_unstemmed | A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy |
| title_short | A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy |
| title_sort | molecular study of aspirin and tenofovir using gold dextran nanocomposites and surface enhanced raman spectroscopy |
| topic | aspirin tenofovir gold nanoparticles dextran chemical sensors SERS |
| url | https://www.mdpi.com/1420-3049/27/8/2554 |
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