Comparison of kinetic and enzymatic properties of intracellular phosphoserine aminotransferases from alkaliphilic and neutralophilic bacteria

Comparison of kinetic and enzymatic properties of intracellular phosphoserine aminotransferases from alkaliphilic and neutralophilic bacteria

Intracellular pyridoxal 5´-phosphate (PLP) -dependent recombinant phosphoserine aminotransferases (PSATs; EC 2.6.1.52) from two alkaliphilic Bacillus strains were overproduced in Escherichia coli, purified to homogeneity and their enzymological characteristics were compared to PSAT from neutralophil...

Full description

Bibliographic Details
Main Authors:	Koivulehto Marianne, Battchikova Natalia, Korpela Saara, Khalikova Elvira, Zavialov Anton, Korpela Timo
Format:	Article
Language:	English
Published:	De Gruyter 2020-03-01
Series:	Open Chemistry
Subjects:	pyridoxal 5´-phosphate dependent enzymes phosphoserine aminotransferase protons at the active site of transaminases
Online Access:	https://doi.org/10.1515/chem-2020-0014

Similar Items

Molecular Structure of Phosphoserine Aminotransferase from <i>Saccharomyces cerevisiae</i>
by: Jiyeon Jang, et al.
Published: (2023-03-01)

Overexpression of Phosphoserine Aminotransferase (<i>PSAT</i>)-Enhanced Cadmium Resistance and Accumulation in Duckweed (<i>Lemna turionifera</i> 5511)
by: Xu Ma, et al.
Published: (2024-02-01)

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization
by: Francesco Marchesani, et al.
Published: (2023-08-01)

Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells
by: Rumeysa Biyik-Sit, et al.
Published: (2021-08-01)

Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis
by: Bartosz Sekula, et al.
Published: (2018-07-01)

Comparative Proteomic Analysis for a Putative Pyridoxal Phosphate-Dependent Aminotransferase Required for Virulence in
by: Jongchan Lee, et al.
Published: (2021-12-01)

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma
by: Bingyan Liu, et al.
Published: (2016-07-01)

Diagnostic approach for children with increased serum concentrations of aminotransferases
by: Franco Curci, et al.
Published: (2024-03-01)

Epidemiology and outcomes of marked elevations of alanine aminotransferase >1000 IU/L in an Australian cohort
by: Danny Con, et al.
Published: (2020-04-01)

Impact of increased aspartate aminotransferase to alanine aminotransferase (De Ritis) ratio in prognosis of testicular cancer
by: Sacit Nuri Gorgel, et al.
Published: (2019-05-01)

Quantum Mechanical/Molecular Mechanical Analysis of the Catalytic Mechanism of Phosphoserine Phosphatase
by: Dieter Krachtus, et al.
Published: (2018-12-01)

The Role of Connexin in Cutaneous Adverse Drug Reactions (CADRs) in Patients with Increasing Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)
by: Dyah Ayu Mira Oktarina, et al.
Published: (2021-07-01)

Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting
by: Mirco Dindo, et al.
Published: (2021-04-01)

Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells
by: Fengmin LI, et al.
Published: (2022-05-01)

Molecular and Cellular Studies Reveal Folding Defects of Human Ornithine Aminotransferase Variants Associated With Gyrate Atrophy of the Choroid and Retina
by: Riccardo Montioli, et al.
Published: (2021-07-01)

Correlation between Aspartate Aminotransferase/Alanine Aminotransferase and Prognosis of Hemophagocytic Lymphohistiocytosis in Children
by: SHI Xiaoqi, LUO Nandu, HUANG Jiaojiao, DU Zuochen, HUANG Pei, CAO Xiuli, CHEN Yan, HE Zhixu
Published: (2023-10-01)

Targeting the Serine Pathway: A Promising Approach against Tuberculosis?
by: Marie Haufroid, et al.
Published: (2019-04-01)

AKTIVITAS ASPARTAT AMINOTRANSFERASE (AST) DAN ALANIN TRANSAMINASE (ALT) PADA MONYET EKOR PANJANG (Macaca fascicularis) OBESITAS DI PURA LUHUR ULUWATU, BALI
by: Ayu Paramita Lestari, et al.
Published: (2016-08-01)

Phosphoserine-loaded chitosan membranes promote bone regeneration by activating endogenous stem cells
by: Yue Ke, et al.
Published: (2023-03-01)

Cytocompatibility and Bioactive Ion Release Profiles of Phosphoserine Bone Adhesive: Bridge from In Vitro to In Vivo
by: Kateřina Vrchovecká, et al.
Published: (2022-03-01)

Biochemical and Bioinformatic Studies of Mutations of Residues at the Monomer–Monomer Interface of Human Ornithine Aminotransferase Leading to Gyrate Atrophy of Choroid and Retina
by: Fulvio Floriani, et al.
Published: (2023-02-01)

A Novel Assay for Phosphoserine Phosphatase Exploiting Serine Acetyltransferase as the Coupling Enzyme
by: Francesco Marchesani, et al.
Published: (2021-05-01)

Biochemical Characterization of Aspergillus fumigatus AroH, a Putative Aromatic Amino Acid Aminotransferase
by: Mirco Dindo, et al.
Published: (2018-11-01)

Perfil da aspartato aminotransferase e alanina aminotransferase e biometria do fígado de codornas japonesas Aspartate aminotransferase and alanine aminotransferase profile and biometry of Japanese quails liver
by: Anderson de Almeida Barbosa, et al.
Published: (2010-02-01)

Liver enzymes serum levels in patients with chronic kidney disease on hemodialysis: a comprehensive review
by: Luís Henrique Bezerra Cavalcanti Sette, et al.
Published: (2014-04-01)

A Novel Aminoacyl-tRNA Synthetase Appended Domain Can Supply the Core Synthetase with Its Amino Acid Substrate
by: Marc Muraski, et al.
Published: (2020-11-01)

Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan
by: Zeming Liu, et al.
Published: (2021-11-01)

Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study
by: Hirotaka Ochiai, et al.
Published: (2020-11-01)

Association of Alanine Transaminase and Aspartate Aminotransferase/Alanine Transaminase Ratio with Type 2 Diabetes and Metabolic Syndrome in the Elderly
by: ZHOU Xiaoqi, LIU Xinhui, ZHANG Wei, LI Changfeng, YAN Yaqiong
Published: (2023-10-01)

Identification and Repurposing of Trisubstituted Harmine Derivatives as Novel Inhibitors of <i>Mycobacterium tuberculosis</i> Phosphoserine Phosphatase
by: Elise Pierson, et al.
Published: (2020-01-01)

Aspartate aminotransferase/alanine aminotransferase ratio and subsequent cancer development
by: Daiki Kobayashi, et al.
Published: (2022-02-01)

The Relationship Between Aspartate Aminotransferase To Alanine Aminotransferase Ratio And Metabolic Syndrome In Adolescents In Northeast China
by: Lin S, et al.
Published: (2019-11-01)

Comparison of the Ornithine Carbamyltransferase with Aspartate Aminotransferase and Alanine Aminotransferase in patients with liver diseases
by: HR.Joshaghani, et al.
Published: (2002-09-01)

Biosynthesis of the Stress-Protectant and Chemical Chaperon Ectoine: Biochemistry of the Transaminase EctB
by: Alexandra A. Richter, et al.
Published: (2019-12-01)

The Effect of Vitamin E Supplementation on Serum Aminotransferases in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis
by: Stamatina Vogli, et al.
Published: (2023-08-01)

Eating quickly is associated with a low aspartate aminotransferase to alanine aminotransferase ratio in middle-aged adults: a large-scale cross-sectional survey in Japan
by: Eri Ozaki, et al.
Published: (2020-10-01)

Hepato-Protective Effects of Silymarin and Coffee in Rats
by: Sidra Mumal, Akbar Waheed, Abdul Azeem, Hira Waqas Cheema, Fakhra Noureen, Abeera Zainab
Published: (2021-12-01)

Prospective analysis of 44 consecutive liver transplants performed at a university hospital
by: Orlando Castro e Silva, et al.
Published: (2013-01-01)

Adhesive Cements That Bond Soft Tissue Ex Vivo
by: Xiuwen Li, et al.
Published: (2019-08-01)

Low aspartate aminotransferase/alanine aminotransferase (DeRitis) ratio assists in predicting diabetes in Chinese population
by: Wangcheng Xie, et al.
Published: (2022-11-01)