Neutrality and robustness in evo-devo: emergence of lateral inhibition.
Embryonic development is defined by the hierarchical dynamical process that translates genetic information (genotype) into a spatial gene expression pattern (phenotype) providing the positional information for the correct unfolding of the organism. The nature and evolutionary implications of genotyp...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-11-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC2577890?pdf=render |
| _version_ | 1818056946846007296 |
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| author | Andreea Munteanu Ricard V Solé |
| author_facet | Andreea Munteanu Ricard V Solé |
| author_sort | Andreea Munteanu |
| collection | DOAJ |
| description | Embryonic development is defined by the hierarchical dynamical process that translates genetic information (genotype) into a spatial gene expression pattern (phenotype) providing the positional information for the correct unfolding of the organism. The nature and evolutionary implications of genotype-phenotype mapping still remain key topics in evolutionary developmental biology (evo-devo). We have explored here issues of neutrality, robustness, and diversity in evo-devo by means of a simple model of gene regulatory networks. The small size of the system allowed an exhaustive analysis of the entire fitness landscape and the extent of its neutrality. This analysis shows that evolution leads to a class of robust genetic networks with an expression pattern characteristic of lateral inhibition. This class is a repertoire of distinct implementations of this key developmental process, the diversity of which provides valuable clues about its underlying causal principles. |
| first_indexed | 2024-12-10T12:36:55Z |
| format | Article |
| id | doaj.art-cd93353aebf54648bf3443a7150995c9 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-10T12:36:55Z |
| publishDate | 2008-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-cd93353aebf54648bf3443a7150995c92022-12-22T01:48:37ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582008-11-01411e100022610.1371/journal.pcbi.1000226Neutrality and robustness in evo-devo: emergence of lateral inhibition.Andreea MunteanuRicard V SoléEmbryonic development is defined by the hierarchical dynamical process that translates genetic information (genotype) into a spatial gene expression pattern (phenotype) providing the positional information for the correct unfolding of the organism. The nature and evolutionary implications of genotype-phenotype mapping still remain key topics in evolutionary developmental biology (evo-devo). We have explored here issues of neutrality, robustness, and diversity in evo-devo by means of a simple model of gene regulatory networks. The small size of the system allowed an exhaustive analysis of the entire fitness landscape and the extent of its neutrality. This analysis shows that evolution leads to a class of robust genetic networks with an expression pattern characteristic of lateral inhibition. This class is a repertoire of distinct implementations of this key developmental process, the diversity of which provides valuable clues about its underlying causal principles.http://europepmc.org/articles/PMC2577890?pdf=render |
| spellingShingle | Andreea Munteanu Ricard V Solé Neutrality and robustness in evo-devo: emergence of lateral inhibition. PLoS Computational Biology |
| title | Neutrality and robustness in evo-devo: emergence of lateral inhibition. |
| title_full | Neutrality and robustness in evo-devo: emergence of lateral inhibition. |
| title_fullStr | Neutrality and robustness in evo-devo: emergence of lateral inhibition. |
| title_full_unstemmed | Neutrality and robustness in evo-devo: emergence of lateral inhibition. |
| title_short | Neutrality and robustness in evo-devo: emergence of lateral inhibition. |
| title_sort | neutrality and robustness in evo devo emergence of lateral inhibition |
| url | http://europepmc.org/articles/PMC2577890?pdf=render |
| work_keys_str_mv | AT andreeamunteanu neutralityandrobustnessinevodevoemergenceoflateralinhibition AT ricardvsole neutralityandrobustnessinevodevoemergenceoflateralinhibition |