Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
Abstract The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Kor...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-77791-8 |
| _version_ | 1819202723762929664 |
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| author | Sang Chul Lee Kang Ju Son Chang Hoon Han Ji Ye Jung Seon Cheol Park |
| author_facet | Sang Chul Lee Kang Ju Son Chang Hoon Han Ji Ye Jung Seon Cheol Park |
| author_sort | Sang Chul Lee |
| collection | DOAJ |
| description | Abstract The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Korean Health Insurance Review and Assessment COVID-19 database for this nationwide retrospective cohort study. Among these, 686 patients with asthma were assessed by their severities and evaluated by the clinical outcome of COVID-19 compared to patients without asthma. Of 7272 adult COVID-19 patients, 686 with asthma and 6586 without asthma were compared. Asthma was not a significant risk factor for respiratory failure or mortality among all COVID-19 patients (odds ratio [OR] = 0.99, P = 0.997 and OR = 1.06, P = 0.759) after adjusting for age, sex, and the Charlson comorbidity score. However, a history of acute exacerbation (OR = 2.63, P = 0.043) was significant risk factors for death among COVID-19 patients with asthma. Asthma is not a risk factor for poor prognosis of COVID-19. However, asthma patients who had any experience of acute exacerbation in the previous year before COVID-19 showed higher COVID-19-related mortality, especially in case of old age and male sex. |
| first_indexed | 2024-12-23T04:08:33Z |
| format | Article |
| id | doaj.art-cd9413f1e8b54c5a898645a7805d99a7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T04:08:33Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cd9413f1e8b54c5a898645a7805d99a72022-12-21T18:00:34ZengNature PortfolioScientific Reports2045-23222020-12-011011910.1038/s41598-020-77791-8Impact of comorbid asthma on severity of coronavirus disease (COVID-19)Sang Chul Lee0Kang Ju Son1Chang Hoon Han2Ji Ye Jung3Seon Cheol Park4Division of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan HospitalDepartment of Research and Analysis, National Health Insurance Service Ilsan HospitalDivision of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan HospitalDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of MedicineDivision of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan HospitalAbstract The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Korean Health Insurance Review and Assessment COVID-19 database for this nationwide retrospective cohort study. Among these, 686 patients with asthma were assessed by their severities and evaluated by the clinical outcome of COVID-19 compared to patients without asthma. Of 7272 adult COVID-19 patients, 686 with asthma and 6586 without asthma were compared. Asthma was not a significant risk factor for respiratory failure or mortality among all COVID-19 patients (odds ratio [OR] = 0.99, P = 0.997 and OR = 1.06, P = 0.759) after adjusting for age, sex, and the Charlson comorbidity score. However, a history of acute exacerbation (OR = 2.63, P = 0.043) was significant risk factors for death among COVID-19 patients with asthma. Asthma is not a risk factor for poor prognosis of COVID-19. However, asthma patients who had any experience of acute exacerbation in the previous year before COVID-19 showed higher COVID-19-related mortality, especially in case of old age and male sex.https://doi.org/10.1038/s41598-020-77791-8 |
| spellingShingle | Sang Chul Lee Kang Ju Son Chang Hoon Han Ji Ye Jung Seon Cheol Park Impact of comorbid asthma on severity of coronavirus disease (COVID-19) Scientific Reports |
| title | Impact of comorbid asthma on severity of coronavirus disease (COVID-19) |
| title_full | Impact of comorbid asthma on severity of coronavirus disease (COVID-19) |
| title_fullStr | Impact of comorbid asthma on severity of coronavirus disease (COVID-19) |
| title_full_unstemmed | Impact of comorbid asthma on severity of coronavirus disease (COVID-19) |
| title_short | Impact of comorbid asthma on severity of coronavirus disease (COVID-19) |
| title_sort | impact of comorbid asthma on severity of coronavirus disease covid 19 |
| url | https://doi.org/10.1038/s41598-020-77791-8 |
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