Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study
Malignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were i...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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SAGE Publishing
2021-06-01
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Series: | Clinical and Applied Thrombosis/Hemostasis |
Online Access: | https://doi.org/10.1177/10760296211024756 |
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author | Hikmat Abdel-Razeq MD Faris Tamimi MD Rashid Abdel-Razeq MD Samer Salah MD Zaid Omari MD Osama Salama MD Alaa Abufara MD Abdalla Al-Tell MD Hanna Qahoush MD Ahmad Nasman MD Ayat Taqash BSc Yazan Alhalaseh MD Rayan Bater MSc |
author_facet | Hikmat Abdel-Razeq MD Faris Tamimi MD Rashid Abdel-Razeq MD Samer Salah MD Zaid Omari MD Osama Salama MD Alaa Abufara MD Abdalla Al-Tell MD Hanna Qahoush MD Ahmad Nasman MD Ayat Taqash BSc Yazan Alhalaseh MD Rayan Bater MSc |
author_sort | Hikmat Abdel-Razeq MD |
collection | DOAJ |
description | Malignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were identified. Clinical and pathological features possibly associated with VTE were reviewed. A total of 322 patients, median age (range) 31 (18-76) years were identified. Tumors were mostly non-seminoma (n = 194, 60.2%), node-positive (n = 130, 40.4%) and 58 (18.0%) had metastatic disease at diagnosis. Venous thromboembolism were confirmed in 27 (8.4%) patients; however, rates were significantly higher ( P < 0.001) in patients with node-positive (18.5%), metastatic disease (22.4%), and those with high lactate dehydrogenase (LDH) (21.3%). Rates were also significantly higher among those who received multiple lines of chemotherapy (27.5%) compared to those who received one line (13.8%) or none (<1.0%), P < 0.001. Patients with testicular tumors and high tumor burden, including nodal involvement, high LDH or metastatic disease, and those treated with multiple lines of chemotherapy have significantly higher rates of VTE. |
first_indexed | 2024-12-21T15:22:25Z |
format | Article |
id | doaj.art-cd9425fd9dda487d837d3dcfb8bc3475 |
institution | Directory Open Access Journal |
issn | 1938-2723 |
language | English |
last_indexed | 2024-12-21T15:22:25Z |
publishDate | 2021-06-01 |
publisher | SAGE Publishing |
record_format | Article |
series | Clinical and Applied Thrombosis/Hemostasis |
spelling | doaj.art-cd9425fd9dda487d837d3dcfb8bc34752022-12-21T18:59:00ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232021-06-012710.1177/10760296211024756Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective StudyHikmat Abdel-Razeq MD0Faris Tamimi MD1Rashid Abdel-Razeq MD2Samer Salah MD3Zaid Omari MD4Osama Salama MD5Alaa Abufara MD6Abdalla Al-Tell MD7Hanna Qahoush MD8Ahmad Nasman MD9Ayat Taqash BSc10Yazan Alhalaseh MD11Rayan Bater MSc12 School of Medicine, University of Jordan, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Istishari Hospital, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Radiology, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Radiology, King Hussein Cancer Center, Amman, Jordan Office of Scientific Affairs and Research, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, JordanMalignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were identified. Clinical and pathological features possibly associated with VTE were reviewed. A total of 322 patients, median age (range) 31 (18-76) years were identified. Tumors were mostly non-seminoma (n = 194, 60.2%), node-positive (n = 130, 40.4%) and 58 (18.0%) had metastatic disease at diagnosis. Venous thromboembolism were confirmed in 27 (8.4%) patients; however, rates were significantly higher ( P < 0.001) in patients with node-positive (18.5%), metastatic disease (22.4%), and those with high lactate dehydrogenase (LDH) (21.3%). Rates were also significantly higher among those who received multiple lines of chemotherapy (27.5%) compared to those who received one line (13.8%) or none (<1.0%), P < 0.001. Patients with testicular tumors and high tumor burden, including nodal involvement, high LDH or metastatic disease, and those treated with multiple lines of chemotherapy have significantly higher rates of VTE.https://doi.org/10.1177/10760296211024756 |
spellingShingle | Hikmat Abdel-Razeq MD Faris Tamimi MD Rashid Abdel-Razeq MD Samer Salah MD Zaid Omari MD Osama Salama MD Alaa Abufara MD Abdalla Al-Tell MD Hanna Qahoush MD Ahmad Nasman MD Ayat Taqash BSc Yazan Alhalaseh MD Rayan Bater MSc Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study Clinical and Applied Thrombosis/Hemostasis |
title | Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study |
title_full | Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study |
title_fullStr | Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study |
title_full_unstemmed | Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study |
title_short | Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study |
title_sort | predictors of venous thromboembolism in patients with testicular germ cell tumors a retrospective study |
url | https://doi.org/10.1177/10760296211024756 |
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