Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study

Malignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were i...

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Main Authors: Hikmat Abdel-Razeq MD, Faris Tamimi MD, Rashid Abdel-Razeq MD, Samer Salah MD, Zaid Omari MD, Osama Salama MD, Alaa Abufara MD, Abdalla Al-Tell MD, Hanna Qahoush MD, Ahmad Nasman MD, Ayat Taqash BSc, Yazan Alhalaseh MD, Rayan Bater MSc
Format: Article
Language:English
Published: SAGE Publishing 2021-06-01
Series:Clinical and Applied Thrombosis/Hemostasis
Online Access:https://doi.org/10.1177/10760296211024756
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author Hikmat Abdel-Razeq MD
Faris Tamimi MD
Rashid Abdel-Razeq MD
Samer Salah MD
Zaid Omari MD
Osama Salama MD
Alaa Abufara MD
Abdalla Al-Tell MD
Hanna Qahoush MD
Ahmad Nasman MD
Ayat Taqash BSc
Yazan Alhalaseh MD
Rayan Bater MSc
author_facet Hikmat Abdel-Razeq MD
Faris Tamimi MD
Rashid Abdel-Razeq MD
Samer Salah MD
Zaid Omari MD
Osama Salama MD
Alaa Abufara MD
Abdalla Al-Tell MD
Hanna Qahoush MD
Ahmad Nasman MD
Ayat Taqash BSc
Yazan Alhalaseh MD
Rayan Bater MSc
author_sort Hikmat Abdel-Razeq MD
collection DOAJ
description Malignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were identified. Clinical and pathological features possibly associated with VTE were reviewed. A total of 322 patients, median age (range) 31 (18-76) years were identified. Tumors were mostly non-seminoma (n = 194, 60.2%), node-positive (n = 130, 40.4%) and 58 (18.0%) had metastatic disease at diagnosis. Venous thromboembolism were confirmed in 27 (8.4%) patients; however, rates were significantly higher ( P < 0.001) in patients with node-positive (18.5%), metastatic disease (22.4%), and those with high lactate dehydrogenase (LDH) (21.3%). Rates were also significantly higher among those who received multiple lines of chemotherapy (27.5%) compared to those who received one line (13.8%) or none (<1.0%), P < 0.001. Patients with testicular tumors and high tumor burden, including nodal involvement, high LDH or metastatic disease, and those treated with multiple lines of chemotherapy have significantly higher rates of VTE.
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spelling doaj.art-cd9425fd9dda487d837d3dcfb8bc34752022-12-21T18:59:00ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232021-06-012710.1177/10760296211024756Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective StudyHikmat Abdel-Razeq MD0Faris Tamimi MD1Rashid Abdel-Razeq MD2Samer Salah MD3Zaid Omari MD4Osama Salama MD5Alaa Abufara MD6Abdalla Al-Tell MD7Hanna Qahoush MD8Ahmad Nasman MD9Ayat Taqash BSc10Yazan Alhalaseh MD11Rayan Bater MSc12 School of Medicine, University of Jordan, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Istishari Hospital, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Radiology, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Radiology, King Hussein Cancer Center, Amman, Jordan Office of Scientific Affairs and Research, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, Jordan Department of Medicine, King Hussein Cancer Center, Amman, JordanMalignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were identified. Clinical and pathological features possibly associated with VTE were reviewed. A total of 322 patients, median age (range) 31 (18-76) years were identified. Tumors were mostly non-seminoma (n = 194, 60.2%), node-positive (n = 130, 40.4%) and 58 (18.0%) had metastatic disease at diagnosis. Venous thromboembolism were confirmed in 27 (8.4%) patients; however, rates were significantly higher ( P < 0.001) in patients with node-positive (18.5%), metastatic disease (22.4%), and those with high lactate dehydrogenase (LDH) (21.3%). Rates were also significantly higher among those who received multiple lines of chemotherapy (27.5%) compared to those who received one line (13.8%) or none (<1.0%), P < 0.001. Patients with testicular tumors and high tumor burden, including nodal involvement, high LDH or metastatic disease, and those treated with multiple lines of chemotherapy have significantly higher rates of VTE.https://doi.org/10.1177/10760296211024756
spellingShingle Hikmat Abdel-Razeq MD
Faris Tamimi MD
Rashid Abdel-Razeq MD
Samer Salah MD
Zaid Omari MD
Osama Salama MD
Alaa Abufara MD
Abdalla Al-Tell MD
Hanna Qahoush MD
Ahmad Nasman MD
Ayat Taqash BSc
Yazan Alhalaseh MD
Rayan Bater MSc
Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study
Clinical and Applied Thrombosis/Hemostasis
title Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study
title_full Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study
title_fullStr Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study
title_full_unstemmed Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study
title_short Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study
title_sort predictors of venous thromboembolism in patients with testicular germ cell tumors a retrospective study
url https://doi.org/10.1177/10760296211024756
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