Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release
Poloxamer is a thermo-sensitive polymer that can form gel at a concentration of 15.0%(mass fraction, the same as below)-30.0%.In order to decrease the gelatinization concentration and improve drug release properties of poloxamer at body temperature, thermo-sensitive N-acetyl glycol chitosan/poloxame...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Journal of Materials Engineering
2020-05-01
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| Series: | Cailiao gongcheng |
| Subjects: | |
| Online Access: | http://jme.biam.ac.cn/CN/Y2020/V48/I5/83 |
| Summary: | Poloxamer is a thermo-sensitive polymer that can form gel at a concentration of 15.0%(mass fraction, the same as below)-30.0%.In order to decrease the gelatinization concentration and improve drug release properties of poloxamer at body temperature, thermo-sensitive N-acetyl glycol chitosan/poloxamer composite hydrogel was prepared by complexing N-acetyl glycol chitosan with poloxamer 407 (GC/P<sub>407</sub>).The structure, thermo-sensitivity, mechanical properties, morphology and <i>in vitro</i> drug release properties of GC/P<sub>407</sub> were characterized by FT-IR, tube inverting method, rheometer, SEM and UV-vis spectroscopy. The GC/P<sub>407</sub> solution shows reversible thermo-sensitive sol-gel transition behavior, and the sol-gel transition temperature is well controlled in the range of 25-37℃ by regulating the ratio of GC/P<sub>407</sub>, which shortens the gelation time and the gelatinization concentration(6%) of poloxamer 407 at body temperature. GC/P<sub>407</sub> composite hydrogel, which has a highly porous three-dimensional structure with pore size of 10-60 μm as demonstrated by SEM, exhibits high mechanical properties. In addition, the GC/P<sub>407</sub> composite hydrogel shows sustained release behavior of the anticancer drug gemcitabine, and the release time of the drug-loaded gel can reach 72 h. GC/P<sub>407</sub> composite hydrogel shows the potential for biomedical application as injectable drug delivery carrier. |
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| ISSN: | 1001-4381 1001-4381 |