Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release
Poloxamer is a thermo-sensitive polymer that can form gel at a concentration of 15.0%(mass fraction, the same as below)-30.0%.In order to decrease the gelatinization concentration and improve drug release properties of poloxamer at body temperature, thermo-sensitive N-acetyl glycol chitosan/poloxame...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Journal of Materials Engineering
2020-05-01
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| Series: | Cailiao gongcheng |
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| Online Access: | http://jme.biam.ac.cn/CN/Y2020/V48/I5/83 |
| _version_ | 1828077061266210816 |
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| author | LI Jin HOU Bing-na HAN Chao-yue NI Kai ZHAO Zi-nian LI Zheng-zheng |
| author_facet | LI Jin HOU Bing-na HAN Chao-yue NI Kai ZHAO Zi-nian LI Zheng-zheng |
| author_sort | LI Jin |
| collection | DOAJ |
| description | Poloxamer is a thermo-sensitive polymer that can form gel at a concentration of 15.0%(mass fraction, the same as below)-30.0%.In order to decrease the gelatinization concentration and improve drug release properties of poloxamer at body temperature, thermo-sensitive N-acetyl glycol chitosan/poloxamer composite hydrogel was prepared by complexing N-acetyl glycol chitosan with poloxamer 407 (GC/P<sub>407</sub>).The structure, thermo-sensitivity, mechanical properties, morphology and <i>in vitro</i> drug release properties of GC/P<sub>407</sub> were characterized by FT-IR, tube inverting method, rheometer, SEM and UV-vis spectroscopy. The GC/P<sub>407</sub> solution shows reversible thermo-sensitive sol-gel transition behavior, and the sol-gel transition temperature is well controlled in the range of 25-37℃ by regulating the ratio of GC/P<sub>407</sub>, which shortens the gelation time and the gelatinization concentration(6%) of poloxamer 407 at body temperature. GC/P<sub>407</sub> composite hydrogel, which has a highly porous three-dimensional structure with pore size of 10-60 μm as demonstrated by SEM, exhibits high mechanical properties. In addition, the GC/P<sub>407</sub> composite hydrogel shows sustained release behavior of the anticancer drug gemcitabine, and the release time of the drug-loaded gel can reach 72 h. GC/P<sub>407</sub> composite hydrogel shows the potential for biomedical application as injectable drug delivery carrier. |
| first_indexed | 2024-04-11T02:25:12Z |
| format | Article |
| id | doaj.art-cd94981aeaee432fb0edf7bc446a5674 |
| institution | Directory Open Access Journal |
| issn | 1001-4381 1001-4381 |
| language | zho |
| last_indexed | 2024-04-11T02:25:12Z |
| publishDate | 2020-05-01 |
| publisher | Journal of Materials Engineering |
| record_format | Article |
| series | Cailiao gongcheng |
| spelling | doaj.art-cd94981aeaee432fb0edf7bc446a56742023-01-02T22:55:38ZzhoJournal of Materials EngineeringCailiao gongcheng1001-43811001-43812020-05-01485839010.11868/j.issn.1001-4381.2019.00100420200411Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug releaseLI Jin0HOU Bing-na1HAN Chao-yue2NI Kai3ZHAO Zi-nian4LI Zheng-zheng5College of Chemical Engineering and Materials, Tianjin University of Science & Technology, Tianjin 300457, China;College of Chemical Engineering and Materials, Tianjin University of Science & Technology, Tianjin 300457, China;College of Chemical Engineering and Materials, Tianjin University of Science & Technology, Tianjin 300457, China;College of Chemical Engineering and Materials, Tianjin University of Science & Technology, Tianjin 300457, China;College of Chemical Engineering and Materials, Tianjin University of Science & Technology, Tianjin 300457, China;College of Chemical Engineering and Materials, Tianjin University of Science & Technology, Tianjin 300457, China;Poloxamer is a thermo-sensitive polymer that can form gel at a concentration of 15.0%(mass fraction, the same as below)-30.0%.In order to decrease the gelatinization concentration and improve drug release properties of poloxamer at body temperature, thermo-sensitive N-acetyl glycol chitosan/poloxamer composite hydrogel was prepared by complexing N-acetyl glycol chitosan with poloxamer 407 (GC/P<sub>407</sub>).The structure, thermo-sensitivity, mechanical properties, morphology and <i>in vitro</i> drug release properties of GC/P<sub>407</sub> were characterized by FT-IR, tube inverting method, rheometer, SEM and UV-vis spectroscopy. The GC/P<sub>407</sub> solution shows reversible thermo-sensitive sol-gel transition behavior, and the sol-gel transition temperature is well controlled in the range of 25-37℃ by regulating the ratio of GC/P<sub>407</sub>, which shortens the gelation time and the gelatinization concentration(6%) of poloxamer 407 at body temperature. GC/P<sub>407</sub> composite hydrogel, which has a highly porous three-dimensional structure with pore size of 10-60 μm as demonstrated by SEM, exhibits high mechanical properties. In addition, the GC/P<sub>407</sub> composite hydrogel shows sustained release behavior of the anticancer drug gemcitabine, and the release time of the drug-loaded gel can reach 72 h. GC/P<sub>407</sub> composite hydrogel shows the potential for biomedical application as injectable drug delivery carrier.http://jme.biam.ac.cn/CN/Y2020/V48/I5/83poloxamern-acetyl glycol chitosansol-gel transitiondrug release carrier |
| spellingShingle | LI Jin HOU Bing-na HAN Chao-yue NI Kai ZHAO Zi-nian LI Zheng-zheng Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release Cailiao gongcheng poloxamer n-acetyl glycol chitosan sol-gel transition drug release carrier |
| title | Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release |
| title_full | Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release |
| title_fullStr | Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release |
| title_full_unstemmed | Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release |
| title_short | Preparation of injectable N-acetyl glycol chitosan/poloxamer composite hydrogel for drug release |
| title_sort | preparation of injectable n acetyl glycol chitosan poloxamer composite hydrogel for drug release |
| topic | poloxamer n-acetyl glycol chitosan sol-gel transition drug release carrier |
| url | http://jme.biam.ac.cn/CN/Y2020/V48/I5/83 |
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