Clinical Application of Circulating Tumor Cells in Gastric Cancer
Early detection and accurate monitoring of cancer is important for improving clinical outcomes. Endoscopic biopsy and/or surgical resection specimens are the gold standard for diagnosing gastric cancer and are also useful for selecting therapeutic strategies based on the analysis of genomic/immune p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Gastroenterology Council for Gut and Liver
2019-02-01
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| Series: | Gut and Liver |
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| Online Access: | http://gutnliver.org/journal/view.html?doi=10.5009/gnl18484 |
| _version_ | 1827257355178344448 |
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| author | Moon Won Lee Gwang Ha Kim Hye Kyung Jeon Su Jin Park |
| author_facet | Moon Won Lee Gwang Ha Kim Hye Kyung Jeon Su Jin Park |
| author_sort | Moon Won Lee |
| collection | DOAJ |
| description | Early detection and accurate monitoring of cancer is important for improving clinical outcomes. Endoscopic biopsy and/or surgical resection specimens are the gold standard for diagnosing gastric cancer and are also useful for selecting therapeutic strategies based on the analysis of genomic/immune parameters. However, these approaches cannot be easily performed because of their invasiveness and because these specimens do not always reflect tumor dynamics and drug sensitivities during therapeutic processes, especially chemotherapy. Accordingly, many researchers have tried to develop noninvasive novel biomarkers that can monitor real-time tumor dynamics for early diagnosis, prognostic evaluation, and prediction of recurrence and therapeutic efficacy. Circulating tumor cells (CTCs) are metastatic cells that are released from the primary tumors into the blood stream and comprise a crucial step in hematogenous metastasis. CTCs, as a liquid biopsy, have received a considerable amount of attention from researchers since they are easily accessible in peripheral blood, avoiding the invasiveness associated with traditional biopsy techniques; they can also be used to derive clinical information for monitoring disease status. In this review, with respect to CTCs, we summarize the metastatic cascade, detection methods, clinical applications, and prospects for patients with gastric cancer. |
| first_indexed | 2025-03-22T01:53:29Z |
| format | Article |
| id | doaj.art-cd9515d04a8644f18db2cf50b879fe1e |
| institution | Directory Open Access Journal |
| issn | 1976-2283 |
| language | English |
| last_indexed | 2025-03-22T01:53:29Z |
| publishDate | 2019-02-01 |
| publisher | Gastroenterology Council for Gut and Liver |
| record_format | Article |
| series | Gut and Liver |
| spelling | doaj.art-cd9515d04a8644f18db2cf50b879fe1e2024-05-08T02:31:26ZengGastroenterology Council for Gut and LiverGut and Liver1976-22832019-02-0113439440110.5009/gnl18484gnl18484Clinical Application of Circulating Tumor Cells in Gastric CancerMoon Won Lee0Gwang Ha Kim1Hye Kyung Jeon2Su Jin Park3Department of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, KoreaEarly detection and accurate monitoring of cancer is important for improving clinical outcomes. Endoscopic biopsy and/or surgical resection specimens are the gold standard for diagnosing gastric cancer and are also useful for selecting therapeutic strategies based on the analysis of genomic/immune parameters. However, these approaches cannot be easily performed because of their invasiveness and because these specimens do not always reflect tumor dynamics and drug sensitivities during therapeutic processes, especially chemotherapy. Accordingly, many researchers have tried to develop noninvasive novel biomarkers that can monitor real-time tumor dynamics for early diagnosis, prognostic evaluation, and prediction of recurrence and therapeutic efficacy. Circulating tumor cells (CTCs) are metastatic cells that are released from the primary tumors into the blood stream and comprise a crucial step in hematogenous metastasis. CTCs, as a liquid biopsy, have received a considerable amount of attention from researchers since they are easily accessible in peripheral blood, avoiding the invasiveness associated with traditional biopsy techniques; they can also be used to derive clinical information for monitoring disease status. In this review, with respect to CTCs, we summarize the metastatic cascade, detection methods, clinical applications, and prospects for patients with gastric cancer.http://gutnliver.org/journal/view.html?doi=10.5009/gnl18484circulating tumor cellsliquid biopsyneoplasmsstomach neoplasms |
| spellingShingle | Moon Won Lee Gwang Ha Kim Hye Kyung Jeon Su Jin Park Clinical Application of Circulating Tumor Cells in Gastric Cancer Gut and Liver circulating tumor cells liquid biopsy neoplasms stomach neoplasms |
| title | Clinical Application of Circulating Tumor Cells in Gastric Cancer |
| title_full | Clinical Application of Circulating Tumor Cells in Gastric Cancer |
| title_fullStr | Clinical Application of Circulating Tumor Cells in Gastric Cancer |
| title_full_unstemmed | Clinical Application of Circulating Tumor Cells in Gastric Cancer |
| title_short | Clinical Application of Circulating Tumor Cells in Gastric Cancer |
| title_sort | clinical application of circulating tumor cells in gastric cancer |
| topic | circulating tumor cells liquid biopsy neoplasms stomach neoplasms |
| url | http://gutnliver.org/journal/view.html?doi=10.5009/gnl18484 |
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