Generation of Orthotopic Patient-Derived Xenografts in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma

Generation of Orthotopic Patient-Derived Xenografts in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma

Current methodologies for developing PDX in humanized mice in preclinical trials with immune-based therapies are limited by GVHD. Here, we compared two approaches for establishing PDX tumors in humanized mice: (1) PDX are first established in immune-deficient mice; or (2) PDX are initially establish...

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Bibliographic Details
Main Authors: Chi Yan, Caroline A. Nebhan, Nabil Saleh, Rebecca Shattuck-Brandt, Sheau-Chiann Chen, Gregory D. Ayers, Vivian Weiss, Ann Richmond, Anna E. Vilgelm
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
patient-derived xenograft
humanized mice
targeted therapy
immunotherapy
melanoma
Online Access:https://www.mdpi.com/2072-6694/15/14/3695

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https://www.mdpi.com/2072-6694/15/14/3695

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