Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review
(1) Background: Nanomedicine, incorporating various nanoparticles and nanomaterials, offers significant potential in medical practice. Its clinical adoption, however, faces challenges like safety concerns, regulatory hurdles, and biocompatibility issues. Despite these, recent advancements have led t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/185 |
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| author | Stefana Maria Moisa Alexandru Burlacu Lacramioara Ionela Butnariu Corina Maria Vasile Crischentian Brinza Elena Lia Spoiala Alexandra Maștaleru Maria Magdalena Leon Solange Tamara Rosu Radu Vatasescu Eliza Elena Cinteză |
| author_facet | Stefana Maria Moisa Alexandru Burlacu Lacramioara Ionela Butnariu Corina Maria Vasile Crischentian Brinza Elena Lia Spoiala Alexandra Maștaleru Maria Magdalena Leon Solange Tamara Rosu Radu Vatasescu Eliza Elena Cinteză |
| author_sort | Stefana Maria Moisa |
| collection | DOAJ |
| description | (1) Background: Nanomedicine, incorporating various nanoparticles and nanomaterials, offers significant potential in medical practice. Its clinical adoption, however, faces challenges like safety concerns, regulatory hurdles, and biocompatibility issues. Despite these, recent advancements have led to the approval of many nanotechnology-based products, including those for pediatric use. (2) Methods: Our approach included reviewing clinical, preclinical, and animal studies, as well as literature reviews from the past two decades and ongoing trials. (3) Results: Nanotechnology has introduced innovative solutions in cardiovascular care, particularly in managing myocardial ischemia. Key developments include drug-eluting stents, nitric oxide-releasing coatings, and the use of magnetic nanoparticles in cardiomyocyte transplantation. These advancements are pivotal for early detection and treatment. In cardiovascular imaging, nanotechnology enables noninvasive assessments. In pediatric cardiology, it holds promise in assisting the development of biological conduits, synthetic valves, and bioartificial grafts for congenital heart defects, and offers new treatments for conditions like dilated cardiomyopathy and pulmonary hypertension. (4) Conclusions: Nanomedicine presents groundbreaking solutions for cardiovascular diseases in both adults and children. It has the potential to transform cardiac care, from enhancing myocardial ischemia treatment and imaging techniques to addressing congenital heart issues. Further research and guideline development are crucial for optimizing its clinical application and revolutionizing patient care. |
| first_indexed | 2024-03-08T09:57:14Z |
| format | Article |
| id | doaj.art-cd9786085ca04cb7a645946cee96e6ef |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:57:14Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cd9786085ca04cb7a645946cee96e6ef2024-01-29T13:47:46ZengMDPI AGBiomedicines2227-90592024-01-0112118510.3390/biomedicines12010185Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive ReviewStefana Maria Moisa0Alexandru Burlacu1Lacramioara Ionela Butnariu2Corina Maria Vasile3Crischentian Brinza4Elena Lia Spoiala5Alexandra Maștaleru6Maria Magdalena Leon7Solange Tamara Rosu8Radu Vatasescu9Eliza Elena Cinteză10Department of Pediatrics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania“Sfanta Maria” Clinical Emergency Hospital for Children, 700309 Iasi, RomaniaPediatric and Adult Congenital Cardiology Department, Centre Hospitalier Universitaire de Bordeaux, 33000 Bordeaux, FranceFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Pediatrics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Specialties I, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Specialties I, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania“Sfanta Maria” Clinical Emergency Hospital for Children, 700309 Iasi, RomaniaCardio-Thoracic Department, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Pediatrics, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania(1) Background: Nanomedicine, incorporating various nanoparticles and nanomaterials, offers significant potential in medical practice. Its clinical adoption, however, faces challenges like safety concerns, regulatory hurdles, and biocompatibility issues. Despite these, recent advancements have led to the approval of many nanotechnology-based products, including those for pediatric use. (2) Methods: Our approach included reviewing clinical, preclinical, and animal studies, as well as literature reviews from the past two decades and ongoing trials. (3) Results: Nanotechnology has introduced innovative solutions in cardiovascular care, particularly in managing myocardial ischemia. Key developments include drug-eluting stents, nitric oxide-releasing coatings, and the use of magnetic nanoparticles in cardiomyocyte transplantation. These advancements are pivotal for early detection and treatment. In cardiovascular imaging, nanotechnology enables noninvasive assessments. In pediatric cardiology, it holds promise in assisting the development of biological conduits, synthetic valves, and bioartificial grafts for congenital heart defects, and offers new treatments for conditions like dilated cardiomyopathy and pulmonary hypertension. (4) Conclusions: Nanomedicine presents groundbreaking solutions for cardiovascular diseases in both adults and children. It has the potential to transform cardiac care, from enhancing myocardial ischemia treatment and imaging techniques to addressing congenital heart issues. Further research and guideline development are crucial for optimizing its clinical application and revolutionizing patient care.https://www.mdpi.com/2227-9059/12/1/185nanotechnologycardiologypediatric cardiology |
| spellingShingle | Stefana Maria Moisa Alexandru Burlacu Lacramioara Ionela Butnariu Corina Maria Vasile Crischentian Brinza Elena Lia Spoiala Alexandra Maștaleru Maria Magdalena Leon Solange Tamara Rosu Radu Vatasescu Eliza Elena Cinteză Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review Biomedicines nanotechnology cardiology pediatric cardiology |
| title | Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review |
| title_full | Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review |
| title_fullStr | Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review |
| title_full_unstemmed | Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review |
| title_short | Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review |
| title_sort | nanotechnology innovations in pediatric cardiology and cardiovascular medicine a comprehensive review |
| topic | nanotechnology cardiology pediatric cardiology |
| url | https://www.mdpi.com/2227-9059/12/1/185 |
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