Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study
Background. In case of high risk of lymph node invasion after endoscopic resection (ER) of superficial esophageal squamous cell carcinoma (SCC), adjuvant chemoradiotherapy (CRT) can be an alternative to surgery. We assessed long-term clinical outcomes of adjuvant therapy by CRT after non-curative ER...
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/590 |
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| author | Arthur Berger Guillaume Perrod Mathieu Pioche Maximilien Barret Elodie Cesbron-Métivier Vincent Lépilliez Marianne Hupé Enrique Perez-Cuadrado-Robles Franck Cholet Augustin Daubigny Charles Texier Einas Abou Ali Edouard Chabrun Jérémie Jacques Timothee Wallenhorst Jean Baptiste Chevaux Marion Schaefer Christophe Cellier Gabriel Rahmi |
| author_facet | Arthur Berger Guillaume Perrod Mathieu Pioche Maximilien Barret Elodie Cesbron-Métivier Vincent Lépilliez Marianne Hupé Enrique Perez-Cuadrado-Robles Franck Cholet Augustin Daubigny Charles Texier Einas Abou Ali Edouard Chabrun Jérémie Jacques Timothee Wallenhorst Jean Baptiste Chevaux Marion Schaefer Christophe Cellier Gabriel Rahmi |
| author_sort | Arthur Berger |
| collection | DOAJ |
| description | Background. In case of high risk of lymph node invasion after endoscopic resection (ER) of superficial esophageal squamous cell carcinoma (SCC), adjuvant chemoradiotherapy (CRT) can be an alternative to surgery. We assessed long-term clinical outcomes of adjuvant therapy by CRT after non-curative ER for superficial SCC. Methods. We performed a retrospective multicenter study. From April 1999 to April 2018, all consecutive patients who underwent ER for SCC with tumor infiltration beyond the muscularis mucosae were included. Results. A total of 137 ER were analyzed. The overall nodal or metastatic recurrence-free survival rate at 5 years was 88% and specific recurrence-free survival rates at 5 years with and without adjuvant therapy were, respectively, 97.9% and 79.1% (<i>p</i> = 0.011). Independent factors for nodal and/or distal metastatic recurrence were age (HR = 1.075, <i>p</i> = 0.031), Sm infiltration depth > 200 µm (HR = 4.129, <i>p</i> = 0.040), and the absence of adjuvant CRT or surgery (HR = 11.322, <i>p</i> = 0.029). Conclusion. In this study, adjuvant therapy is associated with a higher recurrence-free survival rate at 5 years after non-curative ER. This result suggests this approach may be considered as an alternative to surgery in selected patients. |
| first_indexed | 2024-03-11T09:51:27Z |
| format | Article |
| id | doaj.art-cd9869dd3fa642cd9971ee3bd5334e7d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:51:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cd9869dd3fa642cd9971ee3bd5334e7d2023-11-16T16:14:22ZengMDPI AGCancers2072-66942023-01-0115359010.3390/cancers15030590Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western StudyArthur Berger0Guillaume Perrod1Mathieu Pioche2Maximilien Barret3Elodie Cesbron-Métivier4Vincent Lépilliez5Marianne Hupé6Enrique Perez-Cuadrado-Robles7Franck Cholet8Augustin Daubigny9Charles Texier10Einas Abou Ali11Edouard Chabrun12Jérémie Jacques13Timothee Wallenhorst14Jean Baptiste Chevaux15Marion Schaefer16Christophe Cellier17Gabriel Rahmi18CHU Bordeaux, Department of Gastroenterology and Digestive Endoscopy, Univ. Bordeaux, 33000 Bordeaux, FranceDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, FranceDepartment of Hepatology and Gastroenterology, Edouard Herriot Hospital, Lyon 1 University Claude Bernard, 69003 Lyon, FranceDepartment of Gastroenterology and Digestive Endoscopy, Cochin University Hospital, University of Paris, 75014 Paris, FranceDepartment of Hepatology and Gastroenterology, Angers Teaching Hospital, Angers University, 49000 Angers, FranceDepartment of Hepatogastroenterology, Jean Mermoz Private Hospital, Ramsay Santé, 69008 Lyon, FranceCHU Bordeaux, Department of Gastroenterology and Digestive Endoscopy, Univ. Bordeaux, 33000 Bordeaux, FranceDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, FranceDepartment of Hepatology and Gastroenterology, Brest Teaching Hospital, Brest University, 29200 Brest, FranceDepartment of Hepatology and Gastroenterology, Brest Teaching Hospital, Brest University, 29200 Brest, FranceDepartment of Hepatology and Gastroenterology, Angers Teaching Hospital, Angers University, 49000 Angers, FranceDepartment of Gastroenterology and Digestive Endoscopy, Cochin University Hospital, University of Paris, 75014 Paris, FranceCHU Bordeaux, Department of Gastroenterology and Digestive Endoscopy, Univ. Bordeaux, 33000 Bordeaux, FranceDepartment of Hepatology and Gastroenterology, Limoges Teaching Hospital, Limoges University, 87000 Limoges, FranceDepartment of Hepatology and Gastroenterology, Rennes Teaching Hospital, Rennes University, 35033 Rennes, FranceDepartment of Endoscopy and Hepatogastroenterology, Nancy Teaching Hospital, Nancy University, 54000 Nancy, FranceDepartment of Endoscopy and Hepatogastroenterology, Nancy Teaching Hospital, Nancy University, 54000 Nancy, FranceDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, FranceDepartment of Gastroenterology and Digestive Endoscopy, Georges Pompidou European Hospital, Paris-Cité University, 75015 Paris, FranceBackground. In case of high risk of lymph node invasion after endoscopic resection (ER) of superficial esophageal squamous cell carcinoma (SCC), adjuvant chemoradiotherapy (CRT) can be an alternative to surgery. We assessed long-term clinical outcomes of adjuvant therapy by CRT after non-curative ER for superficial SCC. Methods. We performed a retrospective multicenter study. From April 1999 to April 2018, all consecutive patients who underwent ER for SCC with tumor infiltration beyond the muscularis mucosae were included. Results. A total of 137 ER were analyzed. The overall nodal or metastatic recurrence-free survival rate at 5 years was 88% and specific recurrence-free survival rates at 5 years with and without adjuvant therapy were, respectively, 97.9% and 79.1% (<i>p</i> = 0.011). Independent factors for nodal and/or distal metastatic recurrence were age (HR = 1.075, <i>p</i> = 0.031), Sm infiltration depth > 200 µm (HR = 4.129, <i>p</i> = 0.040), and the absence of adjuvant CRT or surgery (HR = 11.322, <i>p</i> = 0.029). Conclusion. In this study, adjuvant therapy is associated with a higher recurrence-free survival rate at 5 years after non-curative ER. This result suggests this approach may be considered as an alternative to surgery in selected patients.https://www.mdpi.com/2072-6694/15/3/590esophageal squamous cell carcinomaendoscopic resectionadjuvant chemoradiotherapyorgan preservation |
| spellingShingle | Arthur Berger Guillaume Perrod Mathieu Pioche Maximilien Barret Elodie Cesbron-Métivier Vincent Lépilliez Marianne Hupé Enrique Perez-Cuadrado-Robles Franck Cholet Augustin Daubigny Charles Texier Einas Abou Ali Edouard Chabrun Jérémie Jacques Timothee Wallenhorst Jean Baptiste Chevaux Marion Schaefer Christophe Cellier Gabriel Rahmi Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study Cancers esophageal squamous cell carcinoma endoscopic resection adjuvant chemoradiotherapy organ preservation |
| title | Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study |
| title_full | Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study |
| title_fullStr | Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study |
| title_full_unstemmed | Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study |
| title_short | Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study |
| title_sort | efficacy of organ preservation strategy by adjuvant chemoradiotherapy after non curative endoscopic resection for superficial scc a multicenter western study |
| topic | esophageal squamous cell carcinoma endoscopic resection adjuvant chemoradiotherapy organ preservation |
| url | https://www.mdpi.com/2072-6694/15/3/590 |
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