APP‐C31: An Intracellular Promoter of Both Metal‐Free and Metal‐Bound Amyloid‐β40 Aggregation and Toxicity in Alzheimer's Disease

APP‐C31: An Intracellular Promoter of Both Metal‐Free and Metal‐Bound Amyloid‐β40 Aggregation and Toxicity in Alzheimer's Disease

Abstract Intracellular C‐terminal cleavage of the amyloid precursor protein (APP) is elevated in the brains of Alzheimer's disease (AD) patients and produces a peptide labeled APP‐C31 that is suspected to be involved in the pathology of AD. But details about the role of APP‐C31 in the developme...

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Bibliographic Details
Main Authors: Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyeon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han, Mu‐Hyun Baik, Young‐Ho Lee, Mi Hee Lim
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advanced Science
Subjects:
accelerator toward amyloidogenesis
amyloid precursor protein
amyloid‐β
metal ions
protein–protein interaction
Online Access:https://doi.org/10.1002/advs.202307182

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