Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin
<p>Abstract</p> <p>Background</p> <p>In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed. We aimed to assess th...
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | http://www.biomedcentral.com/1472-6823/12/6 |
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| author | Jones Angus G Besser Rachel EJ Shields Beverley M McDonald Timothy J Hope Suzy V Knight Bridget A Hattersley Andrew T |
| author_facet | Jones Angus G Besser Rachel EJ Shields Beverley M McDonald Timothy J Hope Suzy V Knight Bridget A Hattersley Andrew T |
| author_sort | Jones Angus G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed. We aimed to assess the impact of endogenous insulin secretion on postprandial glucose increase and the effectiveness of prandial exogenous insulin.</p> <p>Methods</p> <p>We assessed endogenous insulin secretion in 102 participants with insulin treated diabetes (58 Type 1) following a standardised mixed meal without exogenous insulin. We tested the relationship between endogenous insulin secretion and post meal hyperglycaemia. In 80 participants treated with fast acting breakfast insulin we repeated the mixed meal with participants’ usual insulin given and assessed the impact of endogenous insulin secretion on response to exogenous prandial insulin.</p> <p>Results</p> <p>Post meal glucose increment (90 minute - fasting) was inversely correlated with endogenous insulin secretion (90 minute C-peptide) (Spearman’s r = −0.70, p < 0.001). Similar doses of exogenous prandial insulin lowered glucose increment more when patients had less endogenous insulin; by 6.4(4.2-11.1) verses 1.2(0.03-2.88) mmol/L (p < 0.001) for patients in the lowest verses highest tertiles of endogenous insulin.</p> <p>Conclusions</p> <p>In insulin treated patients the measurement of endogenous insulin secretion may help predict the degree of postprandial hyperglycaemia and the likely response to prandial insulin.</p> |
| first_indexed | 2024-12-11T03:48:56Z |
| format | Article |
| id | doaj.art-cd9c21cebe964b398569978fcff91f73 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-11T03:48:56Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-cd9c21cebe964b398569978fcff91f732022-12-22T01:21:57ZengBMCBMC Endocrine Disorders1472-68232012-06-01121610.1186/1472-6823-12-6Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulinJones Angus GBesser Rachel EJShields Beverley MMcDonald Timothy JHope Suzy VKnight Bridget AHattersley Andrew T<p>Abstract</p> <p>Background</p> <p>In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed. We aimed to assess the impact of endogenous insulin secretion on postprandial glucose increase and the effectiveness of prandial exogenous insulin.</p> <p>Methods</p> <p>We assessed endogenous insulin secretion in 102 participants with insulin treated diabetes (58 Type 1) following a standardised mixed meal without exogenous insulin. We tested the relationship between endogenous insulin secretion and post meal hyperglycaemia. In 80 participants treated with fast acting breakfast insulin we repeated the mixed meal with participants’ usual insulin given and assessed the impact of endogenous insulin secretion on response to exogenous prandial insulin.</p> <p>Results</p> <p>Post meal glucose increment (90 minute - fasting) was inversely correlated with endogenous insulin secretion (90 minute C-peptide) (Spearman’s r = −0.70, p < 0.001). Similar doses of exogenous prandial insulin lowered glucose increment more when patients had less endogenous insulin; by 6.4(4.2-11.1) verses 1.2(0.03-2.88) mmol/L (p < 0.001) for patients in the lowest verses highest tertiles of endogenous insulin.</p> <p>Conclusions</p> <p>In insulin treated patients the measurement of endogenous insulin secretion may help predict the degree of postprandial hyperglycaemia and the likely response to prandial insulin.</p>http://www.biomedcentral.com/1472-6823/12/6DiabetesC-peptidePostprandialGlucoseInsulin |
| spellingShingle | Jones Angus G Besser Rachel EJ Shields Beverley M McDonald Timothy J Hope Suzy V Knight Bridget A Hattersley Andrew T Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin BMC Endocrine Disorders Diabetes C-peptide Postprandial Glucose Insulin |
| title | Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin |
| title_full | Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin |
| title_fullStr | Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin |
| title_full_unstemmed | Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin |
| title_short | Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin |
| title_sort | assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin |
| topic | Diabetes C-peptide Postprandial Glucose Insulin |
| url | http://www.biomedcentral.com/1472-6823/12/6 |
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