Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis
A 74-year-old woman with extensive lichen planus mucosae (LPM) developed stenotic esophagitis that was refractory to intravenous glucocorticosteroids. Esophageal dilatations to 14 mm width were repeatedly performed without any lasting effect. After introducing oral apremilast, she experienced comple...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2016-08-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/447051 |
| _version_ | 1819159914720788480 |
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| author | Jürg Hafner Christoph Gubler Karin Kaufmann Stephan Nobbe Alexander A. Navarini Lars E. French |
| author_facet | Jürg Hafner Christoph Gubler Karin Kaufmann Stephan Nobbe Alexander A. Navarini Lars E. French |
| author_sort | Jürg Hafner |
| collection | DOAJ |
| description | A 74-year-old woman with extensive lichen planus mucosae (LPM) developed stenotic esophagitis that was refractory to intravenous glucocorticosteroids. Esophageal dilatations to 14 mm width were repeatedly performed without any lasting effect. After introducing oral apremilast, she experienced complete clinical remission within the first 4 weeks of treatment. Control esophagoscopy confirmed a marked recovery of the esophageal mucosa with no recurrence of the former stenosis. Our observation is in line with the case series of Paul et al. [J Am Acad Dermatol 2013;68: 255–261] who first reported on the benefit of apremilast in patients with extensive LPM. Ideally, the effectiveness of apremilast in LPM should be studied in a randomized controlled trial. |
| first_indexed | 2024-12-22T16:48:08Z |
| format | Article |
| id | doaj.art-cd9cf53fc4334f11bddd22f8061e1555 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-22T16:48:08Z |
| publishDate | 2016-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-cd9cf53fc4334f11bddd22f8061e15552022-12-21T18:19:40ZengKarger PublishersCase Reports in Dermatology1662-65672016-08-018222422610.1159/000447051447051Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic EsophagitisJürg HafnerChristoph GublerKarin KaufmannStephan NobbeAlexander A. NavariniLars E. FrenchA 74-year-old woman with extensive lichen planus mucosae (LPM) developed stenotic esophagitis that was refractory to intravenous glucocorticosteroids. Esophageal dilatations to 14 mm width were repeatedly performed without any lasting effect. After introducing oral apremilast, she experienced complete clinical remission within the first 4 weeks of treatment. Control esophagoscopy confirmed a marked recovery of the esophageal mucosa with no recurrence of the former stenosis. Our observation is in line with the case series of Paul et al. [J Am Acad Dermatol 2013;68: 255–261] who first reported on the benefit of apremilast in patients with extensive LPM. Ideally, the effectiveness of apremilast in LPM should be studied in a randomized controlled trial.http://www.karger.com/Article/FullText/447051Lichen planusLichen planus mucosaeEsophagitisApremilast |
| spellingShingle | Jürg Hafner Christoph Gubler Karin Kaufmann Stephan Nobbe Alexander A. Navarini Lars E. French Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis Case Reports in Dermatology Lichen planus Lichen planus mucosae Esophagitis Apremilast |
| title | Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis |
| title_full | Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis |
| title_fullStr | Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis |
| title_full_unstemmed | Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis |
| title_short | Apremilast Is Effective in Lichen Planus Mucosae-Associated Stenotic Esophagitis |
| title_sort | apremilast is effective in lichen planus mucosae associated stenotic esophagitis |
| topic | Lichen planus Lichen planus mucosae Esophagitis Apremilast |
| url | http://www.karger.com/Article/FullText/447051 |
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