Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial
Abstract Background We determined whether autologous mesenchymal stem cells (MSCs) injections provide clinical and functional improvements in knee osteoarthritis (KOA) patients, and whether the results differ between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Meth...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-03841-2 |
| _version_ | 1797827468738953216 |
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| author | Andrea Pintore Donato Notarfrancesco Arnaldo Zara Antonio Oliviero Filippo Migliorini Francesco Oliva Nicola Maffulli |
| author_facet | Andrea Pintore Donato Notarfrancesco Arnaldo Zara Antonio Oliviero Filippo Migliorini Francesco Oliva Nicola Maffulli |
| author_sort | Andrea Pintore |
| collection | DOAJ |
| description | Abstract Background We determined whether autologous mesenchymal stem cells (MSCs) injections provide clinical and functional improvements in knee osteoarthritis (KOA) patients, and whether the results differ between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Methods Between January 2021 and April 2022, 51 patients undergoing intra-articular injection of BMAC and 51 patients undergoing intra-articular injection of ADSCs were prospectively recruited. The Kellgren and Lawrence (K–L) classification was used to grade the severity of osteoarthritis. Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS), and visual analog scale (VAS) were collected for all 102 patients in the previous week before the procedures, and at the one and 6 months from injection. Results Knee KOOS scores, knee OKS scores, and VAS pain scores changed in similar ways in the two treatment groups. Both treatment groups demonstrated significant improvement pre-procedure to post-procedure in knee KOOS scores (p < 0.0001), knee OKS scores (p < 0.0001), and VAS pain scores (p < 0.0001). Patients with K–L grade 2 showed better functional and clinical outcomes than patients with K–L grades 3 and 4 (p < 0.0001). Conclusion Both intra-articular BMAC and ADSC injections significantly improved pain and functional outcomes at 6-month follow-up in patients with KOA. The difference between BMAC and ADCSs groups as tissue sources of MSCs was not statistically significant in terms of clinical and functional outcomes. |
| first_indexed | 2024-04-09T12:48:48Z |
| format | Article |
| id | doaj.art-cd9eb2a3880e4251b9b8e7b0212f67c3 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-09T12:48:48Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-cd9eb2a3880e4251b9b8e7b0212f67c32023-05-14T11:22:27ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-05-0118111210.1186/s13018-023-03841-2Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trialAndrea Pintore0Donato Notarfrancesco1Arnaldo Zara2Antonio Oliviero3Filippo Migliorini4Francesco Oliva5Nicola Maffulli6Department of Medicine, Surgery and Dentistry, University of SalernoCasa di Cura SalusCasa di Cura SalusDepartment of Medicine, Surgery and Dentistry, University of SalernoDepartment of Orthopaedic, Trauma, and Reconstructive Surgery, University Clinic Aachen, RWTH Aachen University ClinicDepartment of Medicine, Surgery and Dentistry, University of SalernoDepartment of Medicine, Surgery and Dentistry, University of SalernoAbstract Background We determined whether autologous mesenchymal stem cells (MSCs) injections provide clinical and functional improvements in knee osteoarthritis (KOA) patients, and whether the results differ between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Methods Between January 2021 and April 2022, 51 patients undergoing intra-articular injection of BMAC and 51 patients undergoing intra-articular injection of ADSCs were prospectively recruited. The Kellgren and Lawrence (K–L) classification was used to grade the severity of osteoarthritis. Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS), and visual analog scale (VAS) were collected for all 102 patients in the previous week before the procedures, and at the one and 6 months from injection. Results Knee KOOS scores, knee OKS scores, and VAS pain scores changed in similar ways in the two treatment groups. Both treatment groups demonstrated significant improvement pre-procedure to post-procedure in knee KOOS scores (p < 0.0001), knee OKS scores (p < 0.0001), and VAS pain scores (p < 0.0001). Patients with K–L grade 2 showed better functional and clinical outcomes than patients with K–L grades 3 and 4 (p < 0.0001). Conclusion Both intra-articular BMAC and ADSC injections significantly improved pain and functional outcomes at 6-month follow-up in patients with KOA. The difference between BMAC and ADCSs groups as tissue sources of MSCs was not statistically significant in terms of clinical and functional outcomes.https://doi.org/10.1186/s13018-023-03841-2KneeOsteoarthritisMesenchymal stem cellsBone marrowAdipose |
| spellingShingle | Andrea Pintore Donato Notarfrancesco Arnaldo Zara Antonio Oliviero Filippo Migliorini Francesco Oliva Nicola Maffulli Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial Journal of Orthopaedic Surgery and Research Knee Osteoarthritis Mesenchymal stem cells Bone marrow Adipose |
| title | Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial |
| title_full | Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial |
| title_fullStr | Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial |
| title_full_unstemmed | Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial |
| title_short | Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial |
| title_sort | intra articular injection of bone marrow aspirate concentrate bmac or adipose derived stem cells adscs for knee osteoarthritis a prospective comparative clinical trial |
| topic | Knee Osteoarthritis Mesenchymal stem cells Bone marrow Adipose |
| url | https://doi.org/10.1186/s13018-023-03841-2 |
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