Health Effects of Particulate Uranium Exposure
Uranium contamination has become a nonnegligible global health problem. Inhalation of particulate uranium is one of the predominant routes of occupational and environmental exposure. Uranium particle is a complex two-phase flow of matter that is both particulate and flowable. This particular physico...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/10/575 |
| _version_ | 1797469800645001216 |
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| author | Liandong Zhang Jian Chu Binyuan Xia Zhonghua Xiong Shaoyu Zhang Wei Tang |
| author_facet | Liandong Zhang Jian Chu Binyuan Xia Zhonghua Xiong Shaoyu Zhang Wei Tang |
| author_sort | Liandong Zhang |
| collection | DOAJ |
| description | Uranium contamination has become a nonnegligible global health problem. Inhalation of particulate uranium is one of the predominant routes of occupational and environmental exposure. Uranium particle is a complex two-phase flow of matter that is both particulate and flowable. This particular physicochemical property may alter its biological activity. Epidemiological studies from occupationally exposed populations in the uranium industry have concluded that there is a possible association between lung cancer risk and uranium exposure, while the evidence for the risk of other tumors is not sufficient. The toxicological effects of particulate uranium exposure to animals have been shown in laboratory tests to focus on respiratory and central nervous system damage. Fibrosis and tumors can occur in the lung tissue of the respiratory tract. Uranium particles can also induce a concentration-dependent increase in cytotoxicity, targeting mitochondria. The understanding of the health risks and potential toxicological mechanisms of particulate uranium contamination is still at a preliminary stage. The diversity of particle parameters has limited the in-depth exploration. This review summarizes the current evidence on the toxicology of particulate uranium and highlights the knowledge gaps and research prospects. |
| first_indexed | 2024-03-09T19:26:15Z |
| format | Article |
| id | doaj.art-cd9f0ca6923c45f4ad1d1773f2e2a6d5 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T19:26:15Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-cd9f0ca6923c45f4ad1d1773f2e2a6d52023-11-24T02:57:20ZengMDPI AGToxics2305-63042022-09-01101057510.3390/toxics10100575Health Effects of Particulate Uranium ExposureLiandong Zhang0Jian Chu1Binyuan Xia2Zhonghua Xiong3Shaoyu Zhang4Wei Tang5Center for Medical Radiation Biology, 903 Hospital, Institute of Materials, China Academy of Engineering Physics, Mianyang 621907, ChinaCenter for Medical Radiation Biology, 903 Hospital, Institute of Materials, China Academy of Engineering Physics, Mianyang 621907, ChinaCenter for Medical Radiation Biology, 903 Hospital, Institute of Materials, China Academy of Engineering Physics, Mianyang 621907, ChinaCenter for Medical Radiation Biology, 903 Hospital, Institute of Materials, China Academy of Engineering Physics, Mianyang 621907, ChinaCenter for Medical Radiation Biology, 903 Hospital, Institute of Materials, China Academy of Engineering Physics, Mianyang 621907, ChinaCenter for Medical Radiation Biology, 903 Hospital, Institute of Materials, China Academy of Engineering Physics, Mianyang 621907, ChinaUranium contamination has become a nonnegligible global health problem. Inhalation of particulate uranium is one of the predominant routes of occupational and environmental exposure. Uranium particle is a complex two-phase flow of matter that is both particulate and flowable. This particular physicochemical property may alter its biological activity. Epidemiological studies from occupationally exposed populations in the uranium industry have concluded that there is a possible association between lung cancer risk and uranium exposure, while the evidence for the risk of other tumors is not sufficient. The toxicological effects of particulate uranium exposure to animals have been shown in laboratory tests to focus on respiratory and central nervous system damage. Fibrosis and tumors can occur in the lung tissue of the respiratory tract. Uranium particles can also induce a concentration-dependent increase in cytotoxicity, targeting mitochondria. The understanding of the health risks and potential toxicological mechanisms of particulate uranium contamination is still at a preliminary stage. The diversity of particle parameters has limited the in-depth exploration. This review summarizes the current evidence on the toxicology of particulate uranium and highlights the knowledge gaps and research prospects.https://www.mdpi.com/2305-6304/10/10/575particulate uraniumhealth effecttoxicitybiological mechanism |
| spellingShingle | Liandong Zhang Jian Chu Binyuan Xia Zhonghua Xiong Shaoyu Zhang Wei Tang Health Effects of Particulate Uranium Exposure Toxics particulate uranium health effect toxicity biological mechanism |
| title | Health Effects of Particulate Uranium Exposure |
| title_full | Health Effects of Particulate Uranium Exposure |
| title_fullStr | Health Effects of Particulate Uranium Exposure |
| title_full_unstemmed | Health Effects of Particulate Uranium Exposure |
| title_short | Health Effects of Particulate Uranium Exposure |
| title_sort | health effects of particulate uranium exposure |
| topic | particulate uranium health effect toxicity biological mechanism |
| url | https://www.mdpi.com/2305-6304/10/10/575 |
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