A framework for assessing the risk of resistance for anti-malarials in development
<p>Abstract</p> <p>Resistance is a constant challenge for anti-infective drug development. Since they kill sensitive organisms, anti-infective agents are bound to exert an evolutionary pressure toward the emergence and spread of resistance mechanisms, if such resistance can arise b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-08-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://www.malariajournal.com/content/11/1/292 |
| _version_ | 1818565668722704384 |
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| author | Ding Xavier C Ubben David Wells Timothy NC |
| author_facet | Ding Xavier C Ubben David Wells Timothy NC |
| author_sort | Ding Xavier C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Resistance is a constant challenge for anti-infective drug development. Since they kill sensitive organisms, anti-infective agents are bound to exert an evolutionary pressure toward the emergence and spread of resistance mechanisms, if such resistance can arise by stochastic mutation events. New classes of medicines under development must be designed or selected to stay ahead in this vicious circle of resistance control. This involves both circumventing existing resistance mechanisms and selecting molecules which are resilient against the development and spread of resistance. Cell-based screening methods have led to a renaissance of new classes of anti-malarial medicines, offering us the potential to select and modify molecules based on their resistance potential. To that end, a standardized <it>in vitro</it> methodology to assess quantitatively these characteristics in <it>Plasmodium falciparum</it> during the early phases of the drug development process has been developed and is presented here. It allows the identification of anti-malarial compounds with overt resistance risks and the prioritization of the most robust ones. The integration of this strategy in later stages of development, registration, and deployment is also discussed.</p> |
| first_indexed | 2024-12-14T01:44:13Z |
| format | Article |
| id | doaj.art-cd9f4b82b3b143a0b7f24d95f4f1f962 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-14T01:44:13Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-cd9f4b82b3b143a0b7f24d95f4f1f9622022-12-21T23:21:37ZengBMCMalaria Journal1475-28752012-08-0111129210.1186/1475-2875-11-292A framework for assessing the risk of resistance for anti-malarials in developmentDing Xavier CUbben DavidWells Timothy NC<p>Abstract</p> <p>Resistance is a constant challenge for anti-infective drug development. Since they kill sensitive organisms, anti-infective agents are bound to exert an evolutionary pressure toward the emergence and spread of resistance mechanisms, if such resistance can arise by stochastic mutation events. New classes of medicines under development must be designed or selected to stay ahead in this vicious circle of resistance control. This involves both circumventing existing resistance mechanisms and selecting molecules which are resilient against the development and spread of resistance. Cell-based screening methods have led to a renaissance of new classes of anti-malarial medicines, offering us the potential to select and modify molecules based on their resistance potential. To that end, a standardized <it>in vitro</it> methodology to assess quantitatively these characteristics in <it>Plasmodium falciparum</it> during the early phases of the drug development process has been developed and is presented here. It allows the identification of anti-malarial compounds with overt resistance risks and the prioritization of the most robust ones. The integration of this strategy in later stages of development, registration, and deployment is also discussed.</p>http://www.malariajournal.com/content/11/1/292Resistance<it>P. falciparum</it>Drug developmentRisk assessment |
| spellingShingle | Ding Xavier C Ubben David Wells Timothy NC A framework for assessing the risk of resistance for anti-malarials in development Malaria Journal Resistance <it>P. falciparum</it> Drug development Risk assessment |
| title | A framework for assessing the risk of resistance for anti-malarials in development |
| title_full | A framework for assessing the risk of resistance for anti-malarials in development |
| title_fullStr | A framework for assessing the risk of resistance for anti-malarials in development |
| title_full_unstemmed | A framework for assessing the risk of resistance for anti-malarials in development |
| title_short | A framework for assessing the risk of resistance for anti-malarials in development |
| title_sort | framework for assessing the risk of resistance for anti malarials in development |
| topic | Resistance <it>P. falciparum</it> Drug development Risk assessment |
| url | http://www.malariajournal.com/content/11/1/292 |
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