Pregnancy in Women with Arrhythmogenic Left Ventricular Cardiomyopathy
Background: In the last few years, a phenotypic variant of arrhythmogenic cardiomyopathy (ACM) labeled arrhythmogenic left ventricular cardiomyopathy (ALVC) has been defined and researched. This type of cardiomyopathy is characterized by a predominant left ventricular (LV) involvement with no or min...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/22/6735 |
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| author | Riccardo Bariani Maria Bueno Marinas Ilaria Rigato Paola Veronese Rudy Celeghin Alberto Cipriani Marco Cason Valeria Pergola Giulia Mattesi Petra Deola Alessandro Zorzi Giuseppe Limongelli Sabino Iliceto Domenico Corrado Cristina Basso Kalliopi Pilichou Barbara Bauce |
| author_facet | Riccardo Bariani Maria Bueno Marinas Ilaria Rigato Paola Veronese Rudy Celeghin Alberto Cipriani Marco Cason Valeria Pergola Giulia Mattesi Petra Deola Alessandro Zorzi Giuseppe Limongelli Sabino Iliceto Domenico Corrado Cristina Basso Kalliopi Pilichou Barbara Bauce |
| author_sort | Riccardo Bariani |
| collection | DOAJ |
| description | Background: In the last few years, a phenotypic variant of arrhythmogenic cardiomyopathy (ACM) labeled arrhythmogenic left ventricular cardiomyopathy (ALVC) has been defined and researched. This type of cardiomyopathy is characterized by a predominant left ventricular (LV) involvement with no or minor right ventricular (RV) abnormalities. Data on the specific risk and management of pregnancy in women affected by ALVC are, thus far, not available. We have sought to characterize pregnancy course and outcomes in women affected by ALVC through the evaluation of a series of childbearing patients. Methods: A series of consecutive female ALVC patients were analyzed in a cross-sectional, retrospective study. Study protocol included 12-lead ECG assessments, 24-h Holter ECG evaluations, 2D-echocardiogram tests, cardiac magnetic resonance assessments, and genetic analysis. Furthermore, the long-term disease course of childbearing patients was compared with a group of nulliparous ALVC women. Results: A total of 35 patients (mean age 45 ± 9 years, 51% probands) were analyzed. Sixteen women (46%) reported a pregnancy, for a total of 27 singleton viable pregnancies (mean age at first childbirth 30 ± 9 years). Before pregnancy, all patients were in the NYHA class I and none of the patients reported a previous heart failure (HF) episode. No significant differences were found between childbearing and nulliparous women regarding ECG features, LV dimensions, function, and extent of late enhancement. Overall, 7 patients (20%, 4 belonging to the childbearing group) experienced a sustained ventricular tachycardia and 2 (6%)—one for each group—showed heart failure (HF) episodes. The analysis of arrhythmia-free survival patients did not show significant differences between childbearing and nulliparous women. Conclusions: In a cohort of ALVC patients without previous episodes of HF, pregnancy was well tolerated, with no significant influence on disease progression and degree of electrical instability. Further studies on a larger cohort of women with different degrees of disease extent and genetic background are needed in order to achieve a more comprehensive knowledge regarding the outcome of pregnancy in ALVC patients. |
| first_indexed | 2024-03-09T18:15:07Z |
| format | Article |
| id | doaj.art-cd9fa769548243c5a42f23de24e4750d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:15:07Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cd9fa769548243c5a42f23de24e4750d2023-11-24T08:49:14ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011122673510.3390/jcm11226735Pregnancy in Women with Arrhythmogenic Left Ventricular CardiomyopathyRiccardo Bariani0Maria Bueno Marinas1Ilaria Rigato2Paola Veronese3Rudy Celeghin4Alberto Cipriani5Marco Cason6Valeria Pergola7Giulia Mattesi8Petra Deola9Alessandro Zorzi10Giuseppe Limongelli11Sabino Iliceto12Domenico Corrado13Cristina Basso14Kalliopi Pilichou15Barbara Bauce16Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyAzienda Ospedaliera di Padova, Via Giustiniani, 2, 35128 Padova, ItalyAzienda Ospedaliera di Padova, Via Giustiniani, 2, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyAzienda Ospedaliera di Padova, Via Giustiniani, 2, 35128 Padova, ItalyAzienda Ospedaliera di Padova, Via Giustiniani, 2, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Translational Sciences, University della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, ItalyBackground: In the last few years, a phenotypic variant of arrhythmogenic cardiomyopathy (ACM) labeled arrhythmogenic left ventricular cardiomyopathy (ALVC) has been defined and researched. This type of cardiomyopathy is characterized by a predominant left ventricular (LV) involvement with no or minor right ventricular (RV) abnormalities. Data on the specific risk and management of pregnancy in women affected by ALVC are, thus far, not available. We have sought to characterize pregnancy course and outcomes in women affected by ALVC through the evaluation of a series of childbearing patients. Methods: A series of consecutive female ALVC patients were analyzed in a cross-sectional, retrospective study. Study protocol included 12-lead ECG assessments, 24-h Holter ECG evaluations, 2D-echocardiogram tests, cardiac magnetic resonance assessments, and genetic analysis. Furthermore, the long-term disease course of childbearing patients was compared with a group of nulliparous ALVC women. Results: A total of 35 patients (mean age 45 ± 9 years, 51% probands) were analyzed. Sixteen women (46%) reported a pregnancy, for a total of 27 singleton viable pregnancies (mean age at first childbirth 30 ± 9 years). Before pregnancy, all patients were in the NYHA class I and none of the patients reported a previous heart failure (HF) episode. No significant differences were found between childbearing and nulliparous women regarding ECG features, LV dimensions, function, and extent of late enhancement. Overall, 7 patients (20%, 4 belonging to the childbearing group) experienced a sustained ventricular tachycardia and 2 (6%)—one for each group—showed heart failure (HF) episodes. The analysis of arrhythmia-free survival patients did not show significant differences between childbearing and nulliparous women. Conclusions: In a cohort of ALVC patients without previous episodes of HF, pregnancy was well tolerated, with no significant influence on disease progression and degree of electrical instability. Further studies on a larger cohort of women with different degrees of disease extent and genetic background are needed in order to achieve a more comprehensive knowledge regarding the outcome of pregnancy in ALVC patients.https://www.mdpi.com/2077-0383/11/22/6735arrhythmogenic left ventricular cardiomyopathypregnancydesmoplakinfilamin Cplakofillin-2 |
| spellingShingle | Riccardo Bariani Maria Bueno Marinas Ilaria Rigato Paola Veronese Rudy Celeghin Alberto Cipriani Marco Cason Valeria Pergola Giulia Mattesi Petra Deola Alessandro Zorzi Giuseppe Limongelli Sabino Iliceto Domenico Corrado Cristina Basso Kalliopi Pilichou Barbara Bauce Pregnancy in Women with Arrhythmogenic Left Ventricular Cardiomyopathy Journal of Clinical Medicine arrhythmogenic left ventricular cardiomyopathy pregnancy desmoplakin filamin C plakofillin-2 |
| title | Pregnancy in Women with Arrhythmogenic Left Ventricular Cardiomyopathy |
| title_full | Pregnancy in Women with Arrhythmogenic Left Ventricular Cardiomyopathy |
| title_fullStr | Pregnancy in Women with Arrhythmogenic Left Ventricular Cardiomyopathy |
| title_full_unstemmed | Pregnancy in Women with Arrhythmogenic Left Ventricular Cardiomyopathy |
| title_short | Pregnancy in Women with Arrhythmogenic Left Ventricular Cardiomyopathy |
| title_sort | pregnancy in women with arrhythmogenic left ventricular cardiomyopathy |
| topic | arrhythmogenic left ventricular cardiomyopathy pregnancy desmoplakin filamin C plakofillin-2 |
| url | https://www.mdpi.com/2077-0383/11/22/6735 |
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