BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a key regulator of NF-κB signalling) has been recognised as an important oncogenic player in solid tumours. Although reported to be overexpresse...

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Bibliographic Details
Main Authors: Danny N. Legge, Alex P. Shephard, Tracey J. Collard, Alexander Greenhough, Adam C. Chambers, Richard W. Clarkson, Christos Paraskeva, Ann C. Williams
Format: Article
Language:English
Published: The Company of Biologists 2019-03-01
Series:Disease Models & Mechanisms
Subjects:
NF-kappaB
NF-κB
LGR5
ASCL2
Wnt
Spheroid
BCL3
Online Access:http://dmm.biologists.org/content/12/3/dmm037697

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