Report of Haemophilus Influenzae serotype a intracranial infections in older children
ABSTRACT Introduction Haemophilus influenzae (Hi) is subdivided into typeable (a–f) and non‐typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, sp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
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| Series: | Pediatric Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ped4.12369 |
| _version_ | 1797805384908406784 |
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| author | Varvara Probst Fadi Shahoud Aaron Fletcher Osborne Ana Alvarez Nizar Maraqa Ayesha Mirza |
| author_facet | Varvara Probst Fadi Shahoud Aaron Fletcher Osborne Ana Alvarez Nizar Maraqa Ayesha Mirza |
| author_sort | Varvara Probst |
| collection | DOAJ |
| description | ABSTRACT Introduction Haemophilus influenzae (Hi) is subdivided into typeable (a–f) and non‐typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age. Case presentation We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area. Conclusion Epidemiological studies and surveillance on Hia‐related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages. |
| first_indexed | 2024-03-13T05:51:16Z |
| format | Article |
| id | doaj.art-cda0ddc2f5ad433e8c603a3b71382af2 |
| institution | Directory Open Access Journal |
| issn | 2574-2272 |
| language | English |
| last_indexed | 2024-03-13T05:51:16Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pediatric Investigation |
| spelling | doaj.art-cda0ddc2f5ad433e8c603a3b71382af22023-06-13T13:05:31ZengWileyPediatric Investigation2574-22722023-06-017213213610.1002/ped4.12369Report of Haemophilus Influenzae serotype a intracranial infections in older childrenVarvara Probst0Fadi Shahoud1Aaron Fletcher Osborne2Ana Alvarez3Nizar Maraqa4Ayesha Mirza5Department of Pediatrics University of Florida College of Medicine‐Jacksonville Jacksonville Florida USADepartment of Pediatrics University of Florida College of Medicine‐Jacksonville Jacksonville Florida USADepartment of Pediatrics University of Florida College of Medicine‐Jacksonville Jacksonville Florida USADepartment of Pediatrics University of Florida College of Medicine‐Jacksonville Jacksonville Florida USADepartment of Pediatrics Division of Infectious Diseases and Immunology University of Florida College of Medicine‐Jacksonville Jacksonville Florida USADepartment of Pediatrics University of Florida College of Medicine‐Jacksonville Jacksonville Florida USAABSTRACT Introduction Haemophilus influenzae (Hi) is subdivided into typeable (a–f) and non‐typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age. Case presentation We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area. Conclusion Epidemiological studies and surveillance on Hia‐related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.https://doi.org/10.1002/ped4.12369Haemophilus influenzae serotype bintracranial infectionvaccineepidemiology |
| spellingShingle | Varvara Probst Fadi Shahoud Aaron Fletcher Osborne Ana Alvarez Nizar Maraqa Ayesha Mirza Report of Haemophilus Influenzae serotype a intracranial infections in older children Pediatric Investigation Haemophilus influenzae serotype b intracranial infection vaccine epidemiology |
| title | Report of Haemophilus Influenzae serotype a intracranial infections in older children |
| title_full | Report of Haemophilus Influenzae serotype a intracranial infections in older children |
| title_fullStr | Report of Haemophilus Influenzae serotype a intracranial infections in older children |
| title_full_unstemmed | Report of Haemophilus Influenzae serotype a intracranial infections in older children |
| title_short | Report of Haemophilus Influenzae serotype a intracranial infections in older children |
| title_sort | report of haemophilus influenzae serotype a intracranial infections in older children |
| topic | Haemophilus influenzae serotype b intracranial infection vaccine epidemiology |
| url | https://doi.org/10.1002/ped4.12369 |
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