Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial
Abstract This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in func...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-021-00181-0 |
| _version_ | 1797642603598970880 |
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| author | Agurne Sampedro Javier Peña Pedro Sánchez Naroa Ibarretxe-Bilbao Ainara Gómez-Gastiasoro Nagore Iriarte-Yoller Cristóbal Pavón Mikel Tous-Espelosin Natalia Ojeda |
| author_facet | Agurne Sampedro Javier Peña Pedro Sánchez Naroa Ibarretxe-Bilbao Ainara Gómez-Gastiasoro Nagore Iriarte-Yoller Cristóbal Pavón Mikel Tous-Espelosin Natalia Ojeda |
| author_sort | Agurne Sampedro |
| collection | DOAJ |
| description | Abstract This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity. |
| first_indexed | 2024-03-11T14:02:49Z |
| format | Article |
| id | doaj.art-cda1046812ee46aab2e53083d61323c8 |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-11T14:02:49Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-cda1046812ee46aab2e53083d61323c82023-11-02T03:58:34ZengNature Portfolionpj Schizophrenia2334-265X2021-10-017111110.1038/s41537-021-00181-0Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trialAgurne Sampedro0Javier Peña1Pedro Sánchez2Naroa Ibarretxe-Bilbao3Ainara Gómez-Gastiasoro4Nagore Iriarte-Yoller5Cristóbal Pavón6Mikel Tous-Espelosin7Natalia Ojeda8Department of Psychology, Faculty of Health Sciences, University of DeustoDepartment of Psychology, Faculty of Health Sciences, University of DeustoRefractory Psychosis Unit, Psychiatric Hospital of ÁlavaDepartment of Psychology, Faculty of Health Sciences, University of DeustoDepartment of Psychology, Faculty of Health Sciences, University of DeustoRefractory Psychosis Unit, Psychiatric Hospital of ÁlavaRefractory Psychosis Unit, Psychiatric Hospital of ÁlavaDepartment of Physical Education and Sport, Faculty of Education and Sport, University of the Basque Country (UPV/EHU)Department of Psychology, Faculty of Health Sciences, University of DeustoAbstract This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity.https://doi.org/10.1038/s41537-021-00181-0 |
| spellingShingle | Agurne Sampedro Javier Peña Pedro Sánchez Naroa Ibarretxe-Bilbao Ainara Gómez-Gastiasoro Nagore Iriarte-Yoller Cristóbal Pavón Mikel Tous-Espelosin Natalia Ojeda Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial npj Schizophrenia |
| title | Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial |
| title_full | Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial |
| title_fullStr | Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial |
| title_full_unstemmed | Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial |
| title_short | Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial |
| title_sort | cognitive creative functional and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program a randomized controlled trial |
| url | https://doi.org/10.1038/s41537-021-00181-0 |
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