Study on the independent effect of thyroid hormone based on uric acid level on NAFLD
Abstract Objective This study aims to explain the correlation among non-alcoholic fatty liver disease (NAFLD), hyperuricemia, and thyroid function and to find independent risk factors for each other. Methods Data were obtained from subjects who underwent health examination in the Health Promotion Ce...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-021-00247-w |
| _version_ | 1818572349154263040 |
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| author | Guanqun Chao Liying Chen |
| author_facet | Guanqun Chao Liying Chen |
| author_sort | Guanqun Chao |
| collection | DOAJ |
| description | Abstract Objective This study aims to explain the correlation among non-alcoholic fatty liver disease (NAFLD), hyperuricemia, and thyroid function and to find independent risk factors for each other. Methods Data were obtained from subjects who underwent health examination in the Health Promotion Centre of Sir Run Run Shaw Hospital of Zhejiang University from January 2017 to February 2019. The diagnosis of NAFLD was according to the clinical diagnosis of the guidelines. Serum uric acid (SUA) > 360 μmol/L (female) and SUA > 420 μmol/L (male) were enrolled in the hyperuricemia group. R software was used for statistical analysis. Results 55,449 subjects were included in the analysis. 34.27% of patients were classified as NAFLD group (N=19004), and 65.73% of patients were classified as non-NAFLD group (N=36445). The levels of gender ratio, age, BMI, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), HbA1c, triglyceride (TG), high-density lipoprotein (HDLC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN), creatinine (CR), FT3, FT4, and TSH were significantly different between the non-NAFLD group and NAFLD group. Age, BMI, waist circumference, DBP, fFBG, HbA1c, total cholesterol (TC), low-density lipoprotein (LDLC), AST, and UA were all independent risk factors for NAFLD. In the normal uric acid group, variables other than SBP and TSH were independent factors of NAFLD. In the hyperuricemia group, all variables except SBP, FT4, and TSH were independent factors of NAFLD. Conclusion The level of uric acid is related to the occurrence of NAFLD. Hyperuricemia is one of the independent risk factors of NAFLD. TSH level is not related to the occurrence of NAFLD, while FT3 and FT4 may be related to NAFLD. |
| first_indexed | 2024-12-14T18:55:55Z |
| format | Article |
| id | doaj.art-cda124ab085145359a2877cc8ba4a503 |
| institution | Directory Open Access Journal |
| issn | 2072-1315 |
| language | English |
| last_indexed | 2024-12-14T18:55:55Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj.art-cda124ab085145359a2877cc8ba4a5032022-12-21T22:51:05ZengBMCJournal of Health, Population and Nutrition2072-13152021-05-014011710.1186/s41043-021-00247-wStudy on the independent effect of thyroid hormone based on uric acid level on NAFLDGuanqun Chao0Liying Chen1Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of General Practice, Sir Run Run Shaw Hospital, Zhejiang UniversityAbstract Objective This study aims to explain the correlation among non-alcoholic fatty liver disease (NAFLD), hyperuricemia, and thyroid function and to find independent risk factors for each other. Methods Data were obtained from subjects who underwent health examination in the Health Promotion Centre of Sir Run Run Shaw Hospital of Zhejiang University from January 2017 to February 2019. The diagnosis of NAFLD was according to the clinical diagnosis of the guidelines. Serum uric acid (SUA) > 360 μmol/L (female) and SUA > 420 μmol/L (male) were enrolled in the hyperuricemia group. R software was used for statistical analysis. Results 55,449 subjects were included in the analysis. 34.27% of patients were classified as NAFLD group (N=19004), and 65.73% of patients were classified as non-NAFLD group (N=36445). The levels of gender ratio, age, BMI, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), HbA1c, triglyceride (TG), high-density lipoprotein (HDLC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN), creatinine (CR), FT3, FT4, and TSH were significantly different between the non-NAFLD group and NAFLD group. Age, BMI, waist circumference, DBP, fFBG, HbA1c, total cholesterol (TC), low-density lipoprotein (LDLC), AST, and UA were all independent risk factors for NAFLD. In the normal uric acid group, variables other than SBP and TSH were independent factors of NAFLD. In the hyperuricemia group, all variables except SBP, FT4, and TSH were independent factors of NAFLD. Conclusion The level of uric acid is related to the occurrence of NAFLD. Hyperuricemia is one of the independent risk factors of NAFLD. TSH level is not related to the occurrence of NAFLD, while FT3 and FT4 may be related to NAFLD.https://doi.org/10.1186/s41043-021-00247-wNonalcoholic fatty liver diseaseUric acidTSHFT3FT4 |
| spellingShingle | Guanqun Chao Liying Chen Study on the independent effect of thyroid hormone based on uric acid level on NAFLD Journal of Health, Population and Nutrition Nonalcoholic fatty liver disease Uric acid TSH FT3 FT4 |
| title | Study on the independent effect of thyroid hormone based on uric acid level on NAFLD |
| title_full | Study on the independent effect of thyroid hormone based on uric acid level on NAFLD |
| title_fullStr | Study on the independent effect of thyroid hormone based on uric acid level on NAFLD |
| title_full_unstemmed | Study on the independent effect of thyroid hormone based on uric acid level on NAFLD |
| title_short | Study on the independent effect of thyroid hormone based on uric acid level on NAFLD |
| title_sort | study on the independent effect of thyroid hormone based on uric acid level on nafld |
| topic | Nonalcoholic fatty liver disease Uric acid TSH FT3 FT4 |
| url | https://doi.org/10.1186/s41043-021-00247-w |
| work_keys_str_mv | AT guanqunchao studyontheindependenteffectofthyroidhormonebasedonuricacidlevelonnafld AT liyingchen studyontheindependenteffectofthyroidhormonebasedonuricacidlevelonnafld |