Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis
Abstract Heat shock proteins (HSPs) are molecular chaperones that repair denatured proteins. The relationship between HSPs and various diseases has been extensively studied. However, the relationship between HSPs and atherosclerosis remains unclear. In this study, we induced the expression of HSPs a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-86601-8 |
| _version_ | 1818751377773428736 |
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| author | Naoya Hashikawa Masanobu Ido Yuna Morita Narumi Hashikawa-Hobara |
| author_facet | Naoya Hashikawa Masanobu Ido Yuna Morita Narumi Hashikawa-Hobara |
| author_sort | Naoya Hashikawa |
| collection | DOAJ |
| description | Abstract Heat shock proteins (HSPs) are molecular chaperones that repair denatured proteins. The relationship between HSPs and various diseases has been extensively studied. However, the relationship between HSPs and atherosclerosis remains unclear. In this study, we induced the expression of HSPs and analyzed the effects on the development/progression of atherosclerosis in vivo. Remarkably, when HSPs were induced in apolipoprotein E deficient (ApoE−/−) mice prior to the formation of atheromas, the progression of atherosclerosis was inhibited; the short-term induction of HSPs significantly decreased the mRNA expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in the aorta. In contrast, the induction of HSPs after the formation of atheromas promoted the progression of atherosclerosis. In fact, the short-term induction of HSPs, after the formation of atheromas, significantly increased the mRNA expression of tumor necrosis factor-alpha, and interleukin 6 in the aorta. Of note, the induction of HSPs also promoted the formation of macrophage-derived foam cells. Overall, these results indicate that HSPs exerts different effects in the context of aortic atherosclerosis, depending on its degree of progression. Therefore, the induction and inhibition of HSPs should be considered for the prevention and treatment of atherosclerosis, respectively. |
| first_indexed | 2024-12-18T04:34:36Z |
| format | Article |
| id | doaj.art-cda20dfeb40b46dca7c40713396892e4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:34:36Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cda20dfeb40b46dca7c40713396892e42022-12-21T21:20:53ZengNature PortfolioScientific Reports2045-23222021-03-0111111310.1038/s41598-021-86601-8Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosisNaoya Hashikawa0Masanobu Ido1Yuna Morita2Narumi Hashikawa-Hobara3Department of Life Science, Okayama University of ScienceDepartment of Life Science, Okayama University of ScienceDepartment of Life Science, Okayama University of ScienceDepartment of Life Science, Okayama University of ScienceAbstract Heat shock proteins (HSPs) are molecular chaperones that repair denatured proteins. The relationship between HSPs and various diseases has been extensively studied. However, the relationship between HSPs and atherosclerosis remains unclear. In this study, we induced the expression of HSPs and analyzed the effects on the development/progression of atherosclerosis in vivo. Remarkably, when HSPs were induced in apolipoprotein E deficient (ApoE−/−) mice prior to the formation of atheromas, the progression of atherosclerosis was inhibited; the short-term induction of HSPs significantly decreased the mRNA expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in the aorta. In contrast, the induction of HSPs after the formation of atheromas promoted the progression of atherosclerosis. In fact, the short-term induction of HSPs, after the formation of atheromas, significantly increased the mRNA expression of tumor necrosis factor-alpha, and interleukin 6 in the aorta. Of note, the induction of HSPs also promoted the formation of macrophage-derived foam cells. Overall, these results indicate that HSPs exerts different effects in the context of aortic atherosclerosis, depending on its degree of progression. Therefore, the induction and inhibition of HSPs should be considered for the prevention and treatment of atherosclerosis, respectively.https://doi.org/10.1038/s41598-021-86601-8 |
| spellingShingle | Naoya Hashikawa Masanobu Ido Yuna Morita Narumi Hashikawa-Hobara Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis Scientific Reports |
| title | Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis |
| title_full | Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis |
| title_fullStr | Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis |
| title_full_unstemmed | Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis |
| title_short | Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis |
| title_sort | effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis |
| url | https://doi.org/10.1038/s41598-021-86601-8 |
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