The DNA methylome of glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults. This lethal cancer is a challenge in neuro-oncology since patients almost invariably succumb to the disease. Intensive molecular studies have revealed a variety of deregulated genetic pathways involved in DNA repair, apoptosis...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-07-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996110000021 |
| _version_ | 1818734871103668224 |
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| author | Ramon Martinez Manel Esteller |
| author_facet | Ramon Martinez Manel Esteller |
| author_sort | Ramon Martinez |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults. This lethal cancer is a challenge in neuro-oncology since patients almost invariably succumb to the disease. Intensive molecular studies have revealed a variety of deregulated genetic pathways involved in DNA repair, apoptosis, cell migration, angiogenesis and cell cycle. Recent investigation of epigenetic lesions in GBM have led to a more comprehensive understanding of this malignancy and even to target therapies, including the milestone of temozolomide chemotherapy, which makes possible a better outcome for GBM patients with hypermethylated MGMT. Nevertheless, the whole scenario including global hypomethylation, aberrant promoter hypermethylation, histone modification and chromatin states in GBM has only been partially revealed. We discuss the magnitude of epigenetic alterations in the pathogenesis of GBM and their translational relevance to patient survival. |
| first_indexed | 2024-12-18T00:12:14Z |
| format | Article |
| id | doaj.art-cda3af3577ef48e7b965143b9b6477d8 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-18T00:12:14Z |
| publishDate | 2010-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-cda3af3577ef48e7b965143b9b6477d82022-12-21T21:27:38ZengElsevierNeurobiology of Disease1095-953X2010-07-013914046The DNA methylome of glioblastoma multiformeRamon Martinez0Manel Esteller1Department of Neurosurgery, University of Goettingen, Germany; Corresponding authors. R. Martínez is to be contacted at Department of Neurosurgery, University of Goettingen, Robert Koch Str. 40, D-37075 Goettingen, Germany. M. Esteller, Cancer Epigenetics and Biology Program (PEBC), 3rd Floor, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Av. Gran Via de L'Hospitalet 199-203, 08907-L'Hospitalet de Llobregat, Barcelona, Spain.Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain; Corresponding authors. R. Martínez is to be contacted at Department of Neurosurgery, University of Goettingen, Robert Koch Str. 40, D-37075 Goettingen, Germany. M. Esteller, Cancer Epigenetics and Biology Program (PEBC), 3rd Floor, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Av. Gran Via de L'Hospitalet 199-203, 08907-L'Hospitalet de Llobregat, Barcelona, Spain.Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults. This lethal cancer is a challenge in neuro-oncology since patients almost invariably succumb to the disease. Intensive molecular studies have revealed a variety of deregulated genetic pathways involved in DNA repair, apoptosis, cell migration, angiogenesis and cell cycle. Recent investigation of epigenetic lesions in GBM have led to a more comprehensive understanding of this malignancy and even to target therapies, including the milestone of temozolomide chemotherapy, which makes possible a better outcome for GBM patients with hypermethylated MGMT. Nevertheless, the whole scenario including global hypomethylation, aberrant promoter hypermethylation, histone modification and chromatin states in GBM has only been partially revealed. We discuss the magnitude of epigenetic alterations in the pathogenesis of GBM and their translational relevance to patient survival.http://www.sciencedirect.com/science/article/pii/S0969996110000021DNA methylationHypermethylationHypomethylationMicroarraysGlioblastoma multiforme |
| spellingShingle | Ramon Martinez Manel Esteller The DNA methylome of glioblastoma multiforme Neurobiology of Disease DNA methylation Hypermethylation Hypomethylation Microarrays Glioblastoma multiforme |
| title | The DNA methylome of glioblastoma multiforme |
| title_full | The DNA methylome of glioblastoma multiforme |
| title_fullStr | The DNA methylome of glioblastoma multiforme |
| title_full_unstemmed | The DNA methylome of glioblastoma multiforme |
| title_short | The DNA methylome of glioblastoma multiforme |
| title_sort | dna methylome of glioblastoma multiforme |
| topic | DNA methylation Hypermethylation Hypomethylation Microarrays Glioblastoma multiforme |
| url | http://www.sciencedirect.com/science/article/pii/S0969996110000021 |
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