Exosomal miRNA-155-5p from M1-polarized macrophages suppresses angiogenesis by targeting GDF6 to interrupt diabetic wound healing

Exosomal miRNA-155-5p from M1-polarized macrophages suppresses angiogenesis by targeting GDF6 to interrupt diabetic wound healing

Unprogrammed macrophage polarization, especially prolonged activation of proinflammatory macrophages, is associated with delayed wound healing in diabetic objectives. Macrophage-derived exosomes cargo a variety of microRNAs (miRNAs), participating in different stages in wound healing. Here, exosomes...

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Bibliographic Details
Main Authors: Ruohan Lou, Jiali Chen, Fei Zhou, Tian Zhang, Xiuping Chen, Chunming Wang, Bing Guo, Ligen Lin
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
polarized macrophage-derived exosomes
microRNA expression profiles
diabetic wound healing
angiogenesis
growth differentiation factor 6
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123002925

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