Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth
Lung cancer is the most common cause of cancer mortality worldwide. The advances in surgery, radiotherapy, chemotherapeutic and immunotherapeutic drugs have progressed in the past decades, but the prognosis of lung cancer is still poor. In this study, we developed cisplatin (CDDP)-loaded human serum...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222015359 |
| _version_ | 1811177303741300736 |
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| author | Shu-Jyuan Yang Jui-An Pai Ming-Jium Shieh Jenny Ling‑Yu Chen Ke-Cheng Chen |
| author_facet | Shu-Jyuan Yang Jui-An Pai Ming-Jium Shieh Jenny Ling‑Yu Chen Ke-Cheng Chen |
| author_sort | Shu-Jyuan Yang |
| collection | DOAJ |
| description | Lung cancer is the most common cause of cancer mortality worldwide. The advances in surgery, radiotherapy, chemotherapeutic and immunotherapeutic drugs have progressed in the past decades, but the prognosis of lung cancer is still poor. In this study, we developed cisplatin (CDDP)-loaded human serum albumin (HSA)-based gold nanoshells (HCP@GNSs) for synergistic chemo-photothermal therapy (chemo-PTT). The HCP@GNSs not only acted as drug nanocarriers for chemotherapy but also serve as a superior mediator for PTT, which could exhibit a temperature increase upon a near infrared (NIR) laser exposure that was sufficient for photothermal ablation. HCP@GNSs were highly biocompatible and hemocompatible nanocarriers, while the synergistic chemo-PTT resulting from HCP@GNSs plus NIR exposure displayed stronger cytotoxicity effect than HCP@GNSs or PTT alone, especially at a low CDDP concentration. In vivo analysis demonstrated that HCP@GNSs-mediated chemo-PTT increased necrosis in tumors to achieve a high tumor clearance rate with no adverse side effects. Moreover, HCP@GNSs-medicated chemo-PTT induced the recruitment of dendritic cells, B-cells, and natural killer T-cells in distal tumors to inhibit the growth of the tumors. Therefore, the CDDP-loaded HCP@GNSs may be a potential nanomedicine candidate for curative lung cancer treatment in the future. |
| first_indexed | 2024-04-10T22:59:33Z |
| format | Article |
| id | doaj.art-cda793d070744c97882f4b3e0c96fda6 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T22:59:33Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-cda793d070744c97882f4b3e0c96fda62023-01-14T04:25:58ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-02-01158114146Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growthShu-Jyuan Yang0Jui-An Pai1Ming-Jium Shieh2Jenny Ling‑Yu Chen3Ke-Cheng Chen4Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan; Department of Oncology, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei 100, TaiwanDepartment of Radiology, National Taiwan University College of Medicine, Taipei, No. 7, Chung-Shan South Road, Taipei 100, TaiwanInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan; Department of Surgery, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei 100, Taiwan; Corresponding author at: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan.Lung cancer is the most common cause of cancer mortality worldwide. The advances in surgery, radiotherapy, chemotherapeutic and immunotherapeutic drugs have progressed in the past decades, but the prognosis of lung cancer is still poor. In this study, we developed cisplatin (CDDP)-loaded human serum albumin (HSA)-based gold nanoshells (HCP@GNSs) for synergistic chemo-photothermal therapy (chemo-PTT). The HCP@GNSs not only acted as drug nanocarriers for chemotherapy but also serve as a superior mediator for PTT, which could exhibit a temperature increase upon a near infrared (NIR) laser exposure that was sufficient for photothermal ablation. HCP@GNSs were highly biocompatible and hemocompatible nanocarriers, while the synergistic chemo-PTT resulting from HCP@GNSs plus NIR exposure displayed stronger cytotoxicity effect than HCP@GNSs or PTT alone, especially at a low CDDP concentration. In vivo analysis demonstrated that HCP@GNSs-mediated chemo-PTT increased necrosis in tumors to achieve a high tumor clearance rate with no adverse side effects. Moreover, HCP@GNSs-medicated chemo-PTT induced the recruitment of dendritic cells, B-cells, and natural killer T-cells in distal tumors to inhibit the growth of the tumors. Therefore, the CDDP-loaded HCP@GNSs may be a potential nanomedicine candidate for curative lung cancer treatment in the future.http://www.sciencedirect.com/science/article/pii/S0753332222015359Combination therapyChemotherapyPhotothermal therapyHuman serum albuminCisplatinGold nanoshell |
| spellingShingle | Shu-Jyuan Yang Jui-An Pai Ming-Jium Shieh Jenny Ling‑Yu Chen Ke-Cheng Chen Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth Biomedicine & Pharmacotherapy Combination therapy Chemotherapy Photothermal therapy Human serum albumin Cisplatin Gold nanoshell |
| title | Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth |
| title_full | Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth |
| title_fullStr | Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth |
| title_full_unstemmed | Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth |
| title_short | Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth |
| title_sort | cisplatin loaded gold nanoshells mediate chemo photothermal therapy against primary and distal lung cancers growth |
| topic | Combination therapy Chemotherapy Photothermal therapy Human serum albumin Cisplatin Gold nanoshell |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222015359 |
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