Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
The chromatin accessibility landscape and gene regulatory network of pancreatic cancer has not been fully characterised. Here, the authors perform multi-omics analysis of 84 pancreatic cancer organoid lines and reveal gene regulatory networks and distinct molecular subtypes.
Bibliographic Details
| Main Authors: |
Xiaohan Shi,
Yunguang Li,
Qiuyue Yuan,
Shijie Tang,
Shiwei Guo,
Yehan Zhang,
Juan He,
Xiaoyu Zhang,
Ming Han,
Zhuang Liu,
Yiqin Zhu,
Suizhi Gao,
Huan Wang,
Xiongfei Xu,
Kailian Zheng,
Wei Jing,
Luonan Chen,
Yong Wang,
Gang Jin,
Dong Gao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-29857-6
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