The effect of pH alterations on TDP-43 in a cellular model of amyotrophic lateral sclerosis

The effect of pH alterations on TDP-43 in a cellular model of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting motor neurons. The pathophysiology of ALS is not well understood but TDP-43 proteinopathy (aggregation and mislocalization) is one of the major phenomena described. Several factors can influence TDP-43 behavio...

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Bibliographic Details
Main Authors: Yara Al Ojaimi, Charlotte Slek, Samira Osman, Hugo Alarcan, Sylviane Marouillat, Philippe Corcia, Patrick Vourc'h, Débora Lanznaster, Hélène Blasco
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Amyotrophic lateral sclerosis
TDP-43
Aggregates
Mislocalization
pH
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580824000281

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