Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.
The hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by sy...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-01-01
|
Series: | PLoS ONE |
Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295413&type=printable |
_version_ | 1797372005144592384 |
---|---|
author | Arantzazu San Agustín David Crevillén Vanesa Soto-León Juan C Moreno Antonio Oliviero José L Pons |
author_facet | Arantzazu San Agustín David Crevillén Vanesa Soto-León Juan C Moreno Antonio Oliviero José L Pons |
author_sort | Arantzazu San Agustín |
collection | DOAJ |
description | The hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by synchronizing two stimuli in the same neural pathway. However, PAS has not been shown to improve memorization capacity yet. Here, we present an innovative protocol stemming from the PAS paradigm, which combines single-pulse TMS to the hippocampus with endogenous hippocampal activity during a working memory (WM) task. 96 volunteers were randomized across one experimental group and three parallel groups (motor cortex stimulation, sham stimulation, and no stimulation) in a single session. This combined-stimuli configuration resulted in an increased memorization capacity in the WM task, which was dependent on the stimulated brain location and subjects' basal memory performance. These results are potentially significant for clinical research on memory dysfunction and its related neurological disorders. Future research on paired associative or combined stimulation is required to unveil stimulation-derived neural mechanisms that enhance the ability to memorize. |
first_indexed | 2024-03-08T18:29:10Z |
format | Article |
id | doaj.art-cda91bd9815a4d2f95dcc88f563de6cb |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-03-08T18:29:10Z |
publishDate | 2023-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-cda91bd9815a4d2f95dcc88f563de6cb2023-12-30T05:31:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011812e029541310.1371/journal.pone.0295413Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.Arantzazu San AgustínDavid CrevillénVanesa Soto-LeónJuan C MorenoAntonio OlivieroJosé L PonsThe hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by synchronizing two stimuli in the same neural pathway. However, PAS has not been shown to improve memorization capacity yet. Here, we present an innovative protocol stemming from the PAS paradigm, which combines single-pulse TMS to the hippocampus with endogenous hippocampal activity during a working memory (WM) task. 96 volunteers were randomized across one experimental group and three parallel groups (motor cortex stimulation, sham stimulation, and no stimulation) in a single session. This combined-stimuli configuration resulted in an increased memorization capacity in the WM task, which was dependent on the stimulated brain location and subjects' basal memory performance. These results are potentially significant for clinical research on memory dysfunction and its related neurological disorders. Future research on paired associative or combined stimulation is required to unveil stimulation-derived neural mechanisms that enhance the ability to memorize.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295413&type=printable |
spellingShingle | Arantzazu San Agustín David Crevillén Vanesa Soto-León Juan C Moreno Antonio Oliviero José L Pons Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory. PLoS ONE |
title | Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory. |
title_full | Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory. |
title_fullStr | Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory. |
title_full_unstemmed | Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory. |
title_short | Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory. |
title_sort | transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory |
url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295413&type=printable |
work_keys_str_mv | AT arantzazusanagustin transcranialmagneticstimulationcombinedwithendogenoushumanhippocampalandmotorcorticalactivityenhancesmemory AT davidcrevillen transcranialmagneticstimulationcombinedwithendogenoushumanhippocampalandmotorcorticalactivityenhancesmemory AT vanesasotoleon transcranialmagneticstimulationcombinedwithendogenoushumanhippocampalandmotorcorticalactivityenhancesmemory AT juancmoreno transcranialmagneticstimulationcombinedwithendogenoushumanhippocampalandmotorcorticalactivityenhancesmemory AT antoniooliviero transcranialmagneticstimulationcombinedwithendogenoushumanhippocampalandmotorcorticalactivityenhancesmemory AT joselpons transcranialmagneticstimulationcombinedwithendogenoushumanhippocampalandmotorcorticalactivityenhancesmemory |