Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.

The hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by sy...

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Main Authors: Arantzazu San Agustín, David Crevillén, Vanesa Soto-León, Juan C Moreno, Antonio Oliviero, José L Pons
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295413&type=printable
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author Arantzazu San Agustín
David Crevillén
Vanesa Soto-León
Juan C Moreno
Antonio Oliviero
José L Pons
author_facet Arantzazu San Agustín
David Crevillén
Vanesa Soto-León
Juan C Moreno
Antonio Oliviero
José L Pons
author_sort Arantzazu San Agustín
collection DOAJ
description The hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by synchronizing two stimuli in the same neural pathway. However, PAS has not been shown to improve memorization capacity yet. Here, we present an innovative protocol stemming from the PAS paradigm, which combines single-pulse TMS to the hippocampus with endogenous hippocampal activity during a working memory (WM) task. 96 volunteers were randomized across one experimental group and three parallel groups (motor cortex stimulation, sham stimulation, and no stimulation) in a single session. This combined-stimuli configuration resulted in an increased memorization capacity in the WM task, which was dependent on the stimulated brain location and subjects' basal memory performance. These results are potentially significant for clinical research on memory dysfunction and its related neurological disorders. Future research on paired associative or combined stimulation is required to unveil stimulation-derived neural mechanisms that enhance the ability to memorize.
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spelling doaj.art-cda91bd9815a4d2f95dcc88f563de6cb2023-12-30T05:31:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011812e029541310.1371/journal.pone.0295413Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.Arantzazu San AgustínDavid CrevillénVanesa Soto-LeónJuan C MorenoAntonio OlivieroJosé L PonsThe hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by synchronizing two stimuli in the same neural pathway. However, PAS has not been shown to improve memorization capacity yet. Here, we present an innovative protocol stemming from the PAS paradigm, which combines single-pulse TMS to the hippocampus with endogenous hippocampal activity during a working memory (WM) task. 96 volunteers were randomized across one experimental group and three parallel groups (motor cortex stimulation, sham stimulation, and no stimulation) in a single session. This combined-stimuli configuration resulted in an increased memorization capacity in the WM task, which was dependent on the stimulated brain location and subjects' basal memory performance. These results are potentially significant for clinical research on memory dysfunction and its related neurological disorders. Future research on paired associative or combined stimulation is required to unveil stimulation-derived neural mechanisms that enhance the ability to memorize.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295413&type=printable
spellingShingle Arantzazu San Agustín
David Crevillén
Vanesa Soto-León
Juan C Moreno
Antonio Oliviero
José L Pons
Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.
PLoS ONE
title Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.
title_full Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.
title_fullStr Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.
title_full_unstemmed Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.
title_short Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory.
title_sort transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory
url https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295413&type=printable
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