Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac Surgery

Objective: To compare two techniques of activated clotting time (ACT) measurement by two different devices to evaluate the correlation and agreement between these techniques at different points of time during cardiac surgery. Study Design: Comparative Cross-sectional Study. Study settings: Ca...

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Main Authors: Waqas Alam, Syed Aqeel Hussain, Muhammad Ali, Muhammad Adnan Akram, Muhammad Umar Farooq, Rehan Masroor, Hafsa Khalil, Ayesha Sana
Format: Article
Language:English
Published: Army Medical College Rawalpindi 2022-11-01
Series:Pakistan Armed Forces Medical Journal
Subjects:
Online Access:https://pafmj.org/index.php/PAFMJ/article/view/9550
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author Waqas Alam
Syed Aqeel Hussain
Muhammad Ali
Muhammad Adnan Akram
Muhammad Umar Farooq
Rehan Masroor
Hafsa Khalil
Ayesha Sana
author_facet Waqas Alam
Syed Aqeel Hussain
Muhammad Ali
Muhammad Adnan Akram
Muhammad Umar Farooq
Rehan Masroor
Hafsa Khalil
Ayesha Sana
author_sort Waqas Alam
collection DOAJ
description Objective: To compare two techniques of activated clotting time (ACT) measurement by two different devices to evaluate the correlation and agreement between these techniques at different points of time during cardiac surgery. Study Design: Comparative Cross-sectional Study. Study settings: Cardiac Anesthesia Department, Armed Forces Institute of Cardiology and National Institute of Heart Diseases, Rawalpindi Pakistan, from Feb 2022 to Apr 2022. Methodology: 100 patients undergoing CABG surgery on pump were included by non-probability consecutive sampling technique. Two devices operating on different techniques of measurement were used to measure ACT at four different points of time during surgery. Same sample was used to measure ACT from both devices. Data was collected and analysed by SPSS V.20.0. Pearson's chi square test and paired sample t-test were applied to measure the significance. Linear regression analysis was done to find correlation and Bland Altman plot was used for checking agreement between ACT values from both devices.p-value less than 0.05 was considered significant. Results: Out of 100, male patients were 79 and female patients were 21. Their mean age was 54.18±11.91 years and mean weight was 79.06±18.49 kg. Moderate positive correlation was found with Pearson r value of 0.55. There was poor agreement between the ACTs measured by two devices. On average Hem R measures ACT 63.54±50.83 seconds higher than Hem JSP. Average mean and median values for Hem R group are 400.03±59.39 sec and 397.75sec respectively and for Hem JSP group are 336.49±44.63 sec and 340.5 sec respectively. Conclusion: There is moderate positive correlation but poor agreement between the values of ACT measured by Hem R and Hem JSP due to different techniques of measurement so these should not be used interchangeably.
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spelling doaj.art-cdaa09a58e4746489caf4b6488c9b6fc2023-01-31T08:22:58ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422022-11-0172SUPPL-310.51253/pafmj.v72iSUPPL-3.9550Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac SurgeryWaqas Alam0Syed Aqeel Hussain1Muhammad Ali2Muhammad Adnan Akram3Muhammad Umar Farooq4Rehan Masroor5Hafsa Khalil6Ayesha Sana7Armed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan Objective: To compare two techniques of activated clotting time (ACT) measurement by two different devices to evaluate the correlation and agreement between these techniques at different points of time during cardiac surgery. Study Design: Comparative Cross-sectional Study. Study settings: Cardiac Anesthesia Department, Armed Forces Institute of Cardiology and National Institute of Heart Diseases, Rawalpindi Pakistan, from Feb 2022 to Apr 2022. Methodology: 100 patients undergoing CABG surgery on pump were included by non-probability consecutive sampling technique. Two devices operating on different techniques of measurement were used to measure ACT at four different points of time during surgery. Same sample was used to measure ACT from both devices. Data was collected and analysed by SPSS V.20.0. Pearson's chi square test and paired sample t-test were applied to measure the significance. Linear regression analysis was done to find correlation and Bland Altman plot was used for checking agreement between ACT values from both devices.p-value less than 0.05 was considered significant. Results: Out of 100, male patients were 79 and female patients were 21. Their mean age was 54.18±11.91 years and mean weight was 79.06±18.49 kg. Moderate positive correlation was found with Pearson r value of 0.55. There was poor agreement between the ACTs measured by two devices. On average Hem R measures ACT 63.54±50.83 seconds higher than Hem JSP. Average mean and median values for Hem R group are 400.03±59.39 sec and 397.75sec respectively and for Hem JSP group are 336.49±44.63 sec and 340.5 sec respectively. Conclusion: There is moderate positive correlation but poor agreement between the values of ACT measured by Hem R and Hem JSP due to different techniques of measurement so these should not be used interchangeably. https://pafmj.org/index.php/PAFMJ/article/view/9550Activated clotting timeCABGCardiac surgeryHemochronHeparin
spellingShingle Waqas Alam
Syed Aqeel Hussain
Muhammad Ali
Muhammad Adnan Akram
Muhammad Umar Farooq
Rehan Masroor
Hafsa Khalil
Ayesha Sana
Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac Surgery
Pakistan Armed Forces Medical Journal
Activated clotting time
CABG
Cardiac surgery
Hemochron
Heparin
title Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac Surgery
title_full Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac Surgery
title_fullStr Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac Surgery
title_full_unstemmed Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac Surgery
title_short Comparison of Two Techniques of Measuring Activated Clotting Time During Cardiac Surgery
title_sort comparison of two techniques of measuring activated clotting time during cardiac surgery
topic Activated clotting time
CABG
Cardiac surgery
Hemochron
Heparin
url https://pafmj.org/index.php/PAFMJ/article/view/9550
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AT muhammadadnanakram comparisonoftwotechniquesofmeasuringactivatedclottingtimeduringcardiacsurgery
AT muhammadumarfarooq comparisonoftwotechniquesofmeasuringactivatedclottingtimeduringcardiacsurgery
AT rehanmasroor comparisonoftwotechniquesofmeasuringactivatedclottingtimeduringcardiacsurgery
AT hafsakhalil comparisonoftwotechniquesofmeasuringactivatedclottingtimeduringcardiacsurgery
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