Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern China
ObjectiveThe study aimed to compare the clinical characteristics and short-term outcomes of pediatric and adult Japanese encephalitis (JE) patients in order to find out the differences.MethodsFrom August 2006 to October 2019, 107 patients (62 pediatric patients and 45 adult patients) with JE were en...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1135001/full |
| _version_ | 1797842798618083328 |
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| author | Fangyuan Zhang Guangyin Xu Xiaoyu Zhang Yue Li Dong Li Chunjuan Wang Shougang Guo Shougang Guo |
| author_facet | Fangyuan Zhang Guangyin Xu Xiaoyu Zhang Yue Li Dong Li Chunjuan Wang Shougang Guo Shougang Guo |
| author_sort | Fangyuan Zhang |
| collection | DOAJ |
| description | ObjectiveThe study aimed to compare the clinical characteristics and short-term outcomes of pediatric and adult Japanese encephalitis (JE) patients in order to find out the differences.MethodsFrom August 2006 to October 2019, 107 patients (62 pediatric patients and 45 adult patients) with JE were enrolled. Clinical characteristics and short-term outcomes were analyzed. The short-term outcome of each patient was defined as a good outcome or poor outcome according to their Glasgow Coma Scale (GCS) scores (GCS > 8 vs. GCS ≤ 8) at discharge.ResultsAs for acute complications, the incidence of pulmonary infection was higher in 25 adults (25/45, 55.6%) than in 19 children (19/62, 30.6%; P = 0.01). Upper gastrointestinal bleeding was more common in patients with pulmonary infection, with 10 of these patients experiencing the symptom (10/44, 22.7%) compared to only one patient without pulmonary infection (1/63, 1.6%; P = 0.001). The proportion of mechanical ventilation and admission to the intensive care unit (ICU) for supportive care was higher in patients with pulmonary infection than in patients without infection (P < 0.001, P = 0.008, respectively). The GCS scores at discharge in patients with pulmonary infection (7, 4–12.75) were lower than in patients without pulmonary infection (14, 10-14; P < 0.001). Although the GCS scores at the admission of children (9.5, 7–13) were similar to that of adults (7, 6–13), the GCS scores at the discharge of adults (7, 3.5–13) were lower than that of children (13, 10.75–14; P < 0.001).ConclusionThe short-term outcome of JE was worse in adults. Pulmonary infection was correlated with a high incidence of upper gastrointestinal bleeding, mechanical ventilation, and ICU hospitalization in JE. Pulmonary infection is a prognostic predictor of short-term outcomes in patients with JE. Vaccination for adults should be initiated. |
| first_indexed | 2024-04-09T16:54:06Z |
| format | Article |
| id | doaj.art-cdacce27b3ce4e95b996610c02637434 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T16:54:06Z |
| publishDate | 2023-04-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-cdacce27b3ce4e95b996610c026374342023-04-21T07:17:29ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11350011135001Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern ChinaFangyuan Zhang0Guangyin Xu1Xiaoyu Zhang2Yue Li3Dong Li4Chunjuan Wang5Shougang Guo6Shougang Guo7Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of Neurology, Linyi People's Hospital, Linyi, Shandong, ChinaDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of Neurology, Linyi People's Hospital, Linyi, Shandong, ChinaDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaObjectiveThe study aimed to compare the clinical characteristics and short-term outcomes of pediatric and adult Japanese encephalitis (JE) patients in order to find out the differences.MethodsFrom August 2006 to October 2019, 107 patients (62 pediatric patients and 45 adult patients) with JE were enrolled. Clinical characteristics and short-term outcomes were analyzed. The short-term outcome of each patient was defined as a good outcome or poor outcome according to their Glasgow Coma Scale (GCS) scores (GCS > 8 vs. GCS ≤ 8) at discharge.ResultsAs for acute complications, the incidence of pulmonary infection was higher in 25 adults (25/45, 55.6%) than in 19 children (19/62, 30.6%; P = 0.01). Upper gastrointestinal bleeding was more common in patients with pulmonary infection, with 10 of these patients experiencing the symptom (10/44, 22.7%) compared to only one patient without pulmonary infection (1/63, 1.6%; P = 0.001). The proportion of mechanical ventilation and admission to the intensive care unit (ICU) for supportive care was higher in patients with pulmonary infection than in patients without infection (P < 0.001, P = 0.008, respectively). The GCS scores at discharge in patients with pulmonary infection (7, 4–12.75) were lower than in patients without pulmonary infection (14, 10-14; P < 0.001). Although the GCS scores at the admission of children (9.5, 7–13) were similar to that of adults (7, 6–13), the GCS scores at the discharge of adults (7, 3.5–13) were lower than that of children (13, 10.75–14; P < 0.001).ConclusionThe short-term outcome of JE was worse in adults. Pulmonary infection was correlated with a high incidence of upper gastrointestinal bleeding, mechanical ventilation, and ICU hospitalization in JE. Pulmonary infection is a prognostic predictor of short-term outcomes in patients with JE. Vaccination for adults should be initiated.https://www.frontiersin.org/articles/10.3389/fneur.2023.1135001/fullJapanese encephalitisadultchildrencomplicationsshort-term outcome |
| spellingShingle | Fangyuan Zhang Guangyin Xu Xiaoyu Zhang Yue Li Dong Li Chunjuan Wang Shougang Guo Shougang Guo Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern China Frontiers in Neurology Japanese encephalitis adult children complications short-term outcome |
| title | Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern China |
| title_full | Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern China |
| title_fullStr | Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern China |
| title_full_unstemmed | Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern China |
| title_short | Clinical characteristics and short-term outcomes of Japanese encephalitis in pediatric and adult patients: a retrospective study in Northern China |
| title_sort | clinical characteristics and short term outcomes of japanese encephalitis in pediatric and adult patients a retrospective study in northern china |
| topic | Japanese encephalitis adult children complications short-term outcome |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1135001/full |
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