RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux

RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux

The natural product pectolinarigenin exerts anti-inflammatory activity and anti-tumor effects, and exhibits different biological functions, particularly in autophagy and cell cycle regulation. However, the antineoplastic effect of pectolinarigenin on glioblastoma (GBM) remains unclear. In the presen...

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Bibliographic Details
Main Authors: Haiping Jiang, Dongzhi Zhang, Karpov Denis Aleksandrovich, Junyi Ye, Lixiang Wang, Xiaofeng Chen, Ming Gao, Xinzhuang Wang, Tao Yan, He Yang, Enzhou Lu, Wenwu Liu, Cheng Zhang, Jianing Wu, Penglei Yao, Zhenying Sun, Xuan Rong, Sokhatskii Andrei Timofeevich, Safin Shamil Mahmutovich, Zhixing Zheng, Xin Chen, Shiguang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
pectolinarigenin
glioblastoma
RRM2
CDK1
autophagic flux
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.887294/full

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