Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

ABSTRACTThe blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders. Here, we demonstrate that the transport of human a...

Full description

Bibliographic Details
Main Authors: Jason Tien, Dmitri Leonoudakis, Ralitsa Petrova, Vivian Trinh, Tetsuya Taura, Debapriya Sengupta, Lisa Jo, Angela Sho, Yong Yun, Eric Doan, Anita Jamin, Hussein Hallak, David S. Wilson, Jennifer R. Stratton
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Blood-brain barrier (BBB)
central nervous system (CNS)
immunoglobulin G (IgG)
neonatal fc receptor (FcRn)
transcytosis
Trojan horse
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2229098

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2229098

Similar Items