Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Although most bone fractures typically heal without complications, a small proportion of patients (≤10%) experience delayed healing or potential progression to non-union. Interleukin-1 (IL-1β) plays a crucial role in fracture healing as an early driver of inflammation. However, the effects of IL-1β...

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Bibliographic Details
Main Authors: William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
non-viral gene delivery
scaffold
osteogenesis
immunomodulation
IL-1Ra
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.582012/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.582012/full

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