AAPH or Peroxynitrite-Induced Biorelevant Oxidation of Methyl Caffeate Yields a Potent Antitumor Metabolite

AAPH or Peroxynitrite-Induced Biorelevant Oxidation of Methyl Caffeate Yields a Potent Antitumor Metabolite

Hydroxycinnamic acids represent a versatile group of dietary plant antioxidants. Oxidation of methyl-<i>p</i>-coumarate (<b>pcm</b>) and methyl caffeate (<b>cm</b>) was previously found to yield potent antitumor metabolites. Here, we report the formation of potent...

Full description

Bibliographic Details
Main Authors:	Laura Fási, Ahmed Dhahir Latif, István Zupkó, Sándor Lévai, Miklós Dékány, Zoltán Béni, Árpád Könczöl, György Tibor Balogh, Attila Hunyadi
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Biomolecules
Subjects:	antioxidant hydroxycinnamate methyl <i>p</i>-coumarate methyl caffeate lignan reactive oxygen and nitrogen species
Online Access:	https://www.mdpi.com/2218-273X/10/11/1537

Similar Items

In vitro and in silico analysis of Solanum torvum fruit and methyl caffeate interaction with cholinesterases
by: Maha Aljabri, et al.
Published: (2023-10-01)

Methyl Caffeate Isolated from the Flowers of <i>Prunus persica</i> (L.) Batsch Enhances Glucose-Stimulated Insulin Secretion
by: Dahae Lee, et al.
Published: (2021-02-01)

Isopentyl caffeate as a promising drug for the treatment of leishmaniasis: An in silico and in vivo study
by: Wanessa S. Mota, et al.
Published: (2024-01-01)

β-Cyclodextrin/Isopentyl Caffeate Inclusion Complex: Synthesis, Characterization and Antileishmanial Activity
by: Carine S. F. Marques, et al.
Published: (2020-09-01)

Ethyl caffeate inhibits macrophage polarization via SIRT1/NF-κB to attenuate traumatic heterotopic ossification in mice
by: Hui Wang, et al.
Published: (2023-05-01)

In vitro and in vivo analysis of monotherapy and dual therapy with ethyl caffeate and fluconazole on virulence factors of Candida albicans and systemic candidiasis
by: Tianming Wang, et al.
Published: (2021-12-01)

Morolic Acid 3-<i>O</i>-Caffeate Inhibits Adipogenesis by Regulating Epigenetic Gene Expression
by: Sook In Chae, et al.
Published: (2020-12-01)

Suppressive Activity of <i>Glechoma hederacea</i> Extracts against the Phytopathogenic Oomycete <i>Plasmopara viticola</i>, and First Screening of the Active Metabolites
by: Jesús G. Zorrilla, et al.
Published: (2023-12-01)

Antiangiogenic and apoptotic effects of benzyl caffeate on human umbilical vein endothelial cells (HUVECs) and chick embryo chorioallantoic membrane (CAM): In vitro and in vivo models
by: Ho-Jeong Bang, et al.
Published: (2022-06-01)

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation
by: Phuc-Tan Nguyen, et al.
Published: (2023-06-01)

Phytochemical Investigation for the Main Active Constituents in Arctium lappa L. Cultivated in Iraq
by: Dhuha A.Al-Shammaa, et al.
Published: (2017-02-01)

Promoting Angiogenesis Effect and Molecular Mechanism of Isopropyl Caffeate (KYZ), a Novel Metabolism-Derived Candidate Drug, Based on Integrated Network Pharmacology and Transgenic Zebrafish Models
by: Haotian Kong, et al.
Published: (2022-06-01)

A study of esterification of caffeic acid with methanol using p-toluenesulfonic acid as a catalyst
by: Wang Jun, et al.
Published: (2013-01-01)

<i>Broa</i>, an Ethnic Maize Bread, as a Source of Phenolic Compounds
by: Andreia Bento-Silva, et al.
Published: (2021-04-01)

Hydroxycinnamic Acids and Their Derivatives in <i>Broa</i>, a Traditional Ethnic Maize Bread
by: Andreia Bento-Silva, et al.
Published: (2020-10-01)

Effect of Black Cumin Cake Extract, Octyl Caffeate, and Active Packaging on Antioxidant Properties of Egg-Free Mayonnaise during Storage
by: Katarzyna Włodarczyk, et al.
Published: (2023-05-01)

Sustainable Synthesis of <i>p</i>-Hydroxycinnamic Diacids through Proline-Mediated Knoevenagel Condensation in Ethanol: An Access to Potent Phenolic UV Filters and Radical Scavengers
by: Benjamin Rioux, et al.
Published: (2020-04-01)

Enhanced Aryltetralin Lignans Production in <i>Linum</i> Adventi-Tious Root Cultures
by: Michela Alfieri, et al.
Published: (2021-08-01)

Ethanol and Methyl Jasmonate Fumigation Impact on Quality, Antioxidant Capacity, and Phytochemical Content of Broccoli Florets during Storage
by: Arturo Duarte-Sierra, et al.
Published: (2023-04-01)

Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds
by: Laurine Garros, et al.
Published: (2018-10-01)

<i>p</i>-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects
by: Yong Chool Boo
Published: (2019-08-01)

Characterisation of a Hydroxycinnamic Acid Esterase From the Bifidobacterium longum subsp. longum Taxon
by: Sandra M. Kelly, et al.
Published: (2018-11-01)

CRISPR/Cas9 suppression of OsAT10, a rice BAHD acyltransferase, reduces p-coumaric acid incorporation into arabinoxylan without increasing saccharification
by: Svenning R. Möller, et al.
Published: (2022-07-01)

Organic Salts of <i>p</i>-Coumaric Acid and <i>Trans</i>-Ferulic Acid with Aminopicolines
by: Sosthene Nyomba Kamanda, et al.
Published: (2020-02-01)

Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
by: Vicente Carlos de O. Costa, et al.
Published: (2012-01-01)

Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis
by: Louis M. M. Mouterde, et al.
Published: (2018-09-01)

A New Propolis Type from Changbai Mountains in North-east China: Chemical Composition, Botanical Origin and Biological Activity
by: Xiasen Jiang, et al.
Published: (2019-04-01)

Allelopathy and Identification of Five Allelochemicals in the Leaves of the Aromatic Medicinal Tree <i>Aegle marmelos</i> (L.) Correa
by: Seinn Moh Moh, et al.
Published: (2024-02-01)

Anti-Inflammatory and Analgesic Evaluation of a Phytochemical Intercalated into Layered Double Hydroxide
by: Viviane A. Guilherme, et al.
Published: (2022-04-01)

Novel Poly-(Lactic-Co-Glycolic Acid) Targeted Nanoparticles Conjunct with Antibody for the Enhancement of Antibacterial Activity against <i>Ralstonia solanacearum</i>
by: Xue-Jun Yang, et al.
Published: (2021-06-01)

Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex
by: Anna Tresserra-Rimbau, et al.
Published: (2019-11-01)

Biological Activities of p-Hydroxycinnamic Acids in Maintaining Gut Barrier Integrity and Function
by: Zi-Ying Wang, et al.
Published: (2023-07-01)

The Role of Hydroxycinnamic Acid Amide Pathway in Plant Immunity
by: Saifei Liu, et al.
Published: (2022-06-01)

Spectroscopic (FT-IR, FT-Raman, 1H- and 13C-NMR), Theoretical and Microbiological Study of trans o-Coumaric Acid and Alkali Metal o-Coumarates
by: Małgorzata Kowczyk-Sadowy, et al.
Published: (2015-02-01)

Identification of <i>p</i>-Coumaric Acid and Ethyl <i>p</i>-Coumarate as the Main Phenolic Components of Hemp (<i>Cannabis sativa</i> L.) Roots
by: Chang Min Oh, et al.
Published: (2022-04-01)

Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma
by: Ji-Won Park, et al.
Published: (2022-11-01)

Chemo-Enzymatic Synthesis and Biological Assessment of <i>p</i>-Coumarate Fatty Esters: New Antifungal Agents for Potential Plant Protection
by: Cyrian Thaeder, et al.
Published: (2023-08-01)

Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of <i>Larrea tridentata</i>
by: Akihito Yokosuka, et al.
Published: (2021-10-01)

(+)-Bornyl <i>p</i>-Coumarate Extracted from Stem of <i>Piper betle</i> Induced Apoptosis and Autophagy in Melanoma Cells
by: Yu-Jen Wu, et al.
Published: (2020-05-01)

Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction
by: Aviram Trachtenberg, et al.
Published: (2019-05-01)